UniProt P26349
Exendin-4 (P26349)
Exendin-4 (UniProt P26349): 20 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P26349
- Protein
- Exendin-4
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 1 record with a druggable one
Structures
21 records of P26349 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JRJ | Solution structure of exendin-4 in 30-vol% trifluoroethanol | solution nmr | A | — | — |
| 1JRJ | Solution structure of exendin-4 in 30-vol% trifluoroethanol | solution nmr | A | — | — |
| 3C59 | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | B | — | — |
| 3C59 | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | B | — | — |
| 3C5T | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | B | — | — |
| 3C5T | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | B | — | — |
| 5OTT | Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs | x-ray diffraction | B | — | — |
| 5OTT | Extracellular domain of glp-1 receptor in complex with exendin-4 variant GLY2HCS/THR5HCS | x-ray diffraction | B | — | — |
| 6GDZ | exendin-4 based dual GLP-1/glucagon receptor agonist | solution nmr | A | EVT | — |
| 6GDZ | Exendin-4 based dual glp-1/GLUCAGON receptor agonist | solution nmr | A | NH2, EVT | — |
| 6GE2 | Exendin-4 based dual glp-1/GLUCAGON receptor agonist | solution nmr | A | NH2, EVT | — |
| 7LLL | Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | electron microscopy | P | — | 4 (best 0.74) |
| 7LLL | Exendin-4-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein | electron microscopy | P | — | — |
| 7MLL | Solution structure of exenatide (exendin-4) in 30-vol% trifluoroethanol using cs-rosetta | solution nmr | A | NH2 | — |
| 9G0M | Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 288K | solution nmr | A | — | — |
| 9G0N | Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 299K | solution nmr | A | — | — |
| 9G20 | Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 310K | solution nmr | A | — | — |
| 9G21 | Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 321K | solution nmr | A | — | — |
| 9G2N | Trp-cage fortified Tc5b-Exenatide chimera ( Ex-4-Tc5bDR) at 288K | solution nmr | A | — | — |
| 9G2O | Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bDR) at 299K | solution nmr | A | — | — |
| P26349 | AlphaFold monomer V2.0 prediction for exendin-4 (P26349) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3C59 chain B against the predicted model P26349: TM-score 0.80, RMSD 1.56 Å
- 3C59 chain B against the predicted model P26349: TM-score 0.80, RMSD 1.56 Å
- 3C5T chain B against the predicted model P26349: TM-score 0.78, RMSD 0.57 Å
- 3C5T chain B against the predicted model P26349: TM-score 0.78, RMSD 0.57 Å
- 6GDZ chain A against the predicted model P26349: TM-score 0.77, RMSD 1.65 Å
- 6GDZ chain A against the predicted model P26349: TM-score 0.77, RMSD 1.65 Å
- 7MLL chain A against the predicted model P26349: TM-score 0.71, RMSD 1.58 Å
- 1JRJ chain A against the predicted model P26349: TM-score 0.71, RMSD 1.33 Å
- 1JRJ chain A against the predicted model P26349: TM-score 0.71, RMSD 1.33 Å
- 9G20 chain A against the predicted model P26349: TM-score 0.66, RMSD 1.51 Å
Elsewhere
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