GL1X · GenesisL1 explorer

MolNFT v1 · #180214 · protein

Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2

7KSO: “Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2”. Electron microscopy, 1 ligand (ZN). MolNFT v1 #180214 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7KSO
Type
protein
Length
1,690 residues
Chains
6
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q92800, O75530, Q15022, Q09028, Q6ZN18, Q92833
Ligands
ZN

Structure

electron microscopy · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein395—Q92800
B—protein365—O75530
C—protein420—Q15022
D—protein387—Q09028
E—protein100—Q6ZN18
F—protein23—Q92833

Ligands and binding sites

  • ZN · Zinc ion · metal · 8 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7KSO · Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 · the same entry in another collection · chain E against E, TM-score 1.00
  • O75530 · AlphaFold monomer V2.0 prediction for polycomb protein eed (O75530) · a predicted model of the same protein · chain B against A, TM-score 0.98
  • Q09028 · AlphaFold monomer V2.0 prediction for histone-binding protein RBBP4 (Q09028) · a predicted model of the same protein · chain D against A, TM-score 0.98
  • Q92800 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EZH1 (Q92800) · a predicted model of the same protein · chain A against A, TM-score 0.96
  • Q6ZN18 · AlphaFold monomer V2.0 prediction for zinc finger protein AEBP2 (Q6ZN18) · a predicted model of the same protein · chain E against A, TM-score 0.93
  • Q15022 · AlphaFold monomer V2.0 prediction for polycomb protein SUZ12 (Q15022) · a predicted model of the same protein · chain C against A, TM-score 0.93
  • Q92833 · AlphaFold monomer V2.0 prediction for protein jumonji (Q92833) · a predicted model of the same protein · chain F against A, TM-score 0.40

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