UniProt Q92800
Histone-lysine N-methyltransferase EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (UniProt Q92800), EC 2.1.1.356: 5 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q92800
- Protein
- Histone-lysine N-methyltransferase EZH1
- EC
- 2.1.1.356
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
6 records of Q92800 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7KSO | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | electron microscopy | A | ZN | — |
| 7KSR | PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | electron microscopy | A | ZN | — |
| 7KTP | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | electron microscopy | A | ZN | 10 (best 0.83) |
| 7KTP | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | electron microscopy | A | ZN | — |
| 7TD5 | Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | x-ray diffraction | A, F | ZN | — |
| Q92800 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EZH1 (Q92800) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 5 records
Experiment against prediction
- 7TD5 chain F against the predicted model Q92800: TM-score 0.97, RMSD 1.28 Å
- 7TD5 chain A against the predicted model Q92800: TM-score 0.97, RMSD 1.49 Å
- 7KSR chain A against the predicted model Q92800: TM-score 0.96, RMSD 1.43 Å
- 7KSO chain A against the predicted model Q92800: TM-score 0.96, RMSD 1.49 Å
- 7KTP chain A against the predicted model Q92800: TM-score 0.96, RMSD 1.50 Å
- 7KTP chain A against the predicted model Q92800: TM-score 0.96, RMSD 1.50 Å
Elsewhere
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