UniProt Q6ZN18
Zinc finger protein AEBP2 (Q6ZN18)
Zinc finger protein AEBP2 (UniProt Q6ZN18): 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6ZN18
- Protein
- Zinc finger protein AEBP2
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 2 records with a druggable one
Structures
12 records of Q6ZN18 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WAI | Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex | x-ray diffraction | C, G | — | — |
| 5WAI | Crystal structure of a SUZ12-RBBP4-JARID2-AEBP2 heterotetrameric complex | x-ray diffraction | C, G | — | — |
| 5Y0U | The solution structure of AEBP2 C2H2 zinc fingers | solution nmr | A | ZN | — |
| 5Y1U | Crystal structure of RBBP4 bound to AEBP2 rrk motif | x-ray diffraction | C, D | SO4 | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State | electron microscopy | P | — | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the compact active state | electron microscopy | P | — | — |
| 6C24 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the extended active state | electron microscopy | P | — | — |
| 6WKR | PRC2-AEBP2-JARID2 bound to H2AK119UB1 nucleosome | electron microscopy | P | ZN | — |
| 7KSO | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | electron microscopy | E | — | — |
| 8TB9 | PRC2-J119-450 monomer bound to H1-nucleosome | electron microscopy | Y | — | 5 (best 0.85) |
| 9C8U | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | electron microscopy | F | — | 7 (best 0.86) |
| Q6ZN18 | AlphaFold monomer V2.0 prediction for zinc finger protein AEBP2 (Q6ZN18) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5WAI chain G against the predicted model Q6ZN18: TM-score 0.94, RMSD 0.88 Å
- 5WAI chain G against the predicted model Q6ZN18: TM-score 0.94, RMSD 0.88 Å
- 7KSO chain E against the predicted model Q6ZN18: TM-score 0.93, RMSD 1.02 Å
- 5WAI chain C against the predicted model Q6ZN18: TM-score 0.91, RMSD 1.41 Å
- 5WAI chain C against the predicted model Q6ZN18: TM-score 0.91, RMSD 1.41 Å
- 9C8U chain F against the predicted model Q6ZN18: TM-score 0.91, RMSD 1.50 Å
- 5Y1U chain C against the predicted model Q6ZN18: TM-score 0.91, RMSD 0.16 Å
- 8TB9 chain Y against the predicted model Q6ZN18: TM-score 0.86, RMSD 1.92 Å
- 6C24 chain P against the predicted model Q6ZN18: TM-score 0.85, RMSD 1.24 Å
- 5Y1U chain D against the predicted model Q6ZN18: TM-score 0.84, RMSD 0.22 Å
Elsewhere
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