UniProt Q15022
Polycomb protein SUZ12 (Q15022)
Polycomb protein SUZ12 (UniProt Q15022): 35 experimental structures on GenesisL1, 3 ligands bound, 137 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q15022
- Protein
- Polycomb protein SUZ12
- Experimental structures
- 35
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 137 · 11 records with a druggable one
Structures
35 records of Q15022 in the MolNFT archive: 35 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4W2R | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin… | x-ray diffraction | S, T | — | — |
| 4W2R | Structure of HS/ACPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6… | x-ray diffraction | S, T | — | — |
| 5HYN | Structure of human polycomb repressive complex 2 (PRC2) with oncogenic histone H3K27M peptide | x-ray diffraction | C, H, M, S | — | — |
| 5IJ7 | Structure of Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | S, T | — | — |
| 5IJ7 | Structure of HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | S, T | — | — |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | S, T | — | 12 (best 0.85) |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | S, T | — | — |
| 5LS6 | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | x-ray diffraction | C, F, I, L | — | 11 (best 0.85) |
| 5LS6 | Structure of human polycomb repressive complex 2 (PRC2) with inhibitor | x-ray diffraction | C, F, I, L | — | — |
| 5WAI | Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex | x-ray diffraction | B, F | ZN | — |
| 5WAI | Crystal structure of a SUZ12-RBBP4-JARID2-AEBP2 heterotetrameric complex | x-ray diffraction | B, F | ZN | — |
| 5WAK | Crystal Structure of a Suz12-Rbbp4 Binary Complex | x-ray diffraction | B | ZN | 8 (best 0.70) |
| 5WAK | Crystal structure of a SUZ12-RBBP4 binary complex | x-ray diffraction | B | ZN | — |
| 5WG6 | Human polycomb repressive complex 2 in complex with GSK126 inhibitor | x-ray diffraction | A, C | ZN, A9G | — |
| 6B3W | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethy… | x-ray diffraction | S, T | — | 12 (best 0.80) |
| 6B3W | Structure of HS/ACPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1… | x-ray diffraction | S, T | — | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State | electron microscopy | A, M, Q | — | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the compact active state | electron microscopy | A, M, Q | — | — |
| 6C24 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the extended active state | electron microscopy | A, M, Q | — | — |
| 6NQ3 | Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex | x-ray diffraction | B, F | ZN | — |
| 6NQ3 | Crystal structure of a SUZ12-RBBP4-PHF19-JARID2 heterotetrameric complex | x-ray diffraction | B, F | ZN | — |
| 6WKR | PRC2-AEBP2-JARID2 bound to H2AK119UB1 nucleosome | electron microscopy | A | MG | — |
| 7AT8 | Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | electron microscopy | C | — | — |
| 7KSO | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | electron microscopy | C | ZN | 16 (best 0.85) |
| 7KSO | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | electron microscopy | C | ZN | — |
| 7KSR | PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | electron microscopy | C | — | — |
| 7KTP | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | electron microscopy | C | — | 17 (best 0.75) |
| 7KTP | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | electron microscopy | C | — | — |
| 7TD5 | Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | x-ray diffraction | C, H | — | — |
| 8FYH | G4 RNA-mediated PRC2 dimer | electron microscopy | B, H | — | 16 (best 0.83) |
| 8T9G | Automethylated PRC2 dimer bound to nucleosome | electron microscopy | B, G | — | 13 (best 0.87) |
| 8TAS | PRC2 monomer bound to nucleosome | electron microscopy | D | — | 10 (best 0.88) |
| 8TB9 | PRC2-J119-450 monomer bound to H1-nucleosome | electron microscopy | D | — | 9 (best 0.85) |
| 9C8U | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | electron microscopy | B | — | 13 (best 0.86) |
| Q15022 | AlphaFold monomer V2.0 prediction for polycomb protein SUZ12 (Q15022) | — | — | — |
Ligands
Experiment against prediction
- 5WG6 chain A against the predicted model Q15910: TM-score 0.74, RMSD 1.07 Å
- 5WG6 chain C against the predicted model Q15910: TM-score 0.74, RMSD 1.26 Å
Elsewhere
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