Structure of the GPR88-GI1 signaling complex bound to a synthetic ligand

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• CLR · Cholesterol · ligand · 3 copies · chains R
• J5F · (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide · ligand · chains R, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7EJX · Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand · the same entry in another collection · chain G against G, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
• Q9GZN0 · AlphaFold monomer V2.0 prediction for probable G-protein coupled receptor 88 (Q9GZN0) · a predicted model of the same protein · chain R against A, TM-score 0.92
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9GZN0
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 7EJX · PDBe 7EJX · UniProt Q9GZN0 · UniProt P63096 · UniProt P62873 · UniProt P59768