MolNFT v1 · #176897 · protein
COMPOUND2_GLP-1R_OWL833_GS complex structure
7E14: “COMPOUND2_GLP-1R_OWL833_GS complex structure”. Electron microscopy, 3 ligands (CLR, V6G, HNO). MolNFT v1 #176897 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E14
- Type
- protein
- Length
- 1,089 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P62871, P43220
- Ligands
- CLR, V6G, HNO
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 193 | — | — |
| B | — | protein | 338 | — | P62871 |
| G | — | protein | 57 | — | — |
| N | — | protein | 126 | — | — |
| R | — | protein | 375 | — | P43220 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 5 copies · chains R
- V6G · 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one · ligand · chains R
- HNO · N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7E14 · Compound2_GLP-1R_OWL833_Gs complex structure · the same entry in another collection · chain B against B, TM-score 1.00
- P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62871
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7E14 · PDBe 7E14 · UniProt P62871 · UniProt P43220
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