Structure of a minimal SF3B core in complex with sudemycin D6 (form II)

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• T2W · [(~{Z},2~{S})-5-[[4-[(2~{E},4~{E})-3-methyl-5-[(2~{S}, 4~{R})-4,6,6-trimethyl-4-oxidanyl-oxan-2-yl]penta-2,4-dienyl]cyclohexyl]amino]-5-oxidanylidene-pent-3-en-2-yl] ~{N}-methylcarbamate · ligand · chains C, D
• ZN · Zinc ion · metal · 3 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7B92 · Structure of a minimal SF3B core in complex with sudemycin D6 (form II) · the same entry in another collection · chain D against D, TM-score 1.00
• Q15393 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393) · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q9BWJ5 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 5 (Q9BWJ5) · a predicted model of the same protein · chain B against A, TM-score 0.92
• Q7RTV0 · AlphaFold monomer V2.0 prediction for phd finger-like domain- containing protein 5A… · a predicted model of the same protein · chain D against A, TM-score 0.89
• O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain C against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15393
• Every structure of UniProt Q9BWJ5
• Every structure of UniProt O75533
• Every structure of UniProt Q7RTV0
• Elsewhere: RCSB PDB 7B92 · PDBe 7B92 · UniProt Q15393 · UniProt Q9BWJ5 · UniProt O75533 · UniProt Q7RTV0