MolNFT v1 · #169115 · protein
Non peptide agonist pf-06882961, bound to glucagon-like peptide-1 (glp-1) receptor
6X1A: “Non peptide agonist pf-06882961, bound to glucagon-like peptide-1 (glp-1) receptor”. Electron microscopy, 1 ligand (UK4). MolNFT v1 #169115 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6X1A
- Type
- protein
- Length
- 1,262 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63092, P62873, P59768, P43220
- Ligands
- UK4
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 351 | — | P63092 |
| B | — | protein | 338 | — | P62873 |
| G | — | protein | 57 | — | P59768 |
| N | — | protein | 126 | — | — |
| R | — | protein | 390 | — | P43220 |
Ligands and binding sites
- UK4 · 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6X1A · Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.88
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 6X1A · PDBe 6X1A · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P43220
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