MolNFT v1 · #160755 · protein
Structure of CTF4 trimer in complex with one cmg helicase
6PTJ · DNA replication complex gins protein PSF1: “Structure of CTF4 trimer in complex with one cmg helicase”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #160755 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6PTJ
- Type
- protein
- Length
- 4,280 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA replication complex gins protein PSF1; DNA replication complex gins protein PSF2; DNA…
- EC
- 3.6.4.12
- UniProt
- Q12488, P40359, Q12146, Q03406, Q08032, P29469, P24279, P30665, P29496, P53091, P38132, Q01454
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 14 distinct chains · 25% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA replication complex gins protein PSF1 | protein | 208 | 41% helix, 3% strand | Q12488 |
| B | DNA replication complex gins protein PSF2 | protein | 186 | 29% helix, 4% strand | P40359 |
| C | DNA replication complex gins protein PSF3 | protein | 159 | 31% helix, 10% strand | Q12146 |
| D | DNA replication complex gins protein SLD5 | protein | 230 | 38% helix, 7% strand | Q03406 |
| c | Cell division control protein 45 | protein | 553 | 37% helix, 10% strand | Q08032 |
| 2 | DNA replication licensing factor MCM2 (EC 3.6.4.12) | protein | 260 | 17% helix, 17% strand | P29469 |
| 3 | DNA replication licensing factor MCM3 (EC 3.6.4.12) | protein | 270 | 19% helix, 19% strand | P24279 |
| 4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) | protein | 285 | 18% helix, 22% strand | P30665 |
| 5 | Minichromosome maintenance protein 5 (EC 3.6.4.12) | protein | 252 | 15% helix, 28% strand | P29496 |
| 6 | DNA replication licensing factor MCM6 (EC 3.6.4.12) | protein | 273 | 21% helix, 19% strand | P53091 |
| 7 | DNA replication licensing factor MCM7 (EC 3.6.4.12) | protein | 326 | 17% helix, 17% strand | P38132 |
| E | DNA polymerase alpha-binding protein | protein | 424 | 24% helix, 26% strand | Q01454 |
| F | DNA polymerase alpha-binding protein | protein | 431 | 24% helix, 26% strand | Q01454 |
| G | DNA polymerase alpha-binding protein | protein | 423 | 24% helix, 26% strand | Q01454 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1140 | 0.85 | 0.86 | 125 | empty |
| 2 | 826 | 0.83 | 0.85 | 91 | empty |
| 3 | 975 | 0.82 | 0.83 | 92 | empty |
| 4 | 1124 | 0.80 | 0.81 | 112 | empty |
| 5 | 947 | 0.79 | 0.81 | 96 | empty |
Interfaces
28 interfaces between chains.
- B–D · 2288 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 1951 Ų buried · 22 hydrogen bonds · protein-protein
- 3–7 · 1744 Ų buried · 13 hydrogen bonds · protein-protein
- 4–7 · 1573 Ų buried · 14 hydrogen bonds · protein-protein
- 4–6 · 1498 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6PTJ · Structure of Ctf4 trimer in complex with one CMG helicase · the same entry in another collection · chain 5 against 5, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12488
- Every structure of UniProt P40359
- Every structure of UniProt Q12146
- Every structure of UniProt Q03406
- Every structure of UniProt Q08032
- Every structure of UniProt P29469
- Every structure of UniProt P24279
- Every structure of UniProt P30665
- Every structure of UniProt P29496
- Every structure of UniProt P53091
- Every structure of UniProt P38132
- Every structure of UniProt Q01454
- Elsewhere: RCSB PDB 6PTJ · PDBe 6PTJ · UniProt Q12488 · UniProt P40359 · UniProt Q12146 · UniProt Q03406 · UniProt Q08032 · UniProt P29469 · UniProt P24279 · UniProt P30665 · UniProt P29496 · UniProt P53091 · UniProt P38132 · UniProt Q01454
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.