UniProt P24279
DNA replication licensing factor MCM3 (P24279)
DNA replication licensing factor MCM3 (UniProt P24279), EC 3.6.4.12: 35 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P24279
- Protein
- DNA replication licensing factor MCM3
- EC
- 3.6.4.12
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 56 · 9 records with a druggable one
Structures
36 records of P24279 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JA8 | Cryo-EM structure of the MCM2-7 double hexamer | electron microscopy | 3 | — | — |
| 3JA8 | Cryo-EM structure of the MCM2-7 double hexamer | electron microscopy | 3 | — | — |
| 3JC5 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 3JC5 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 3JC6 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 3JC6 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 3JC7 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 3JC7 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 3 | — | — |
| 5BK4 | Cryo-EM structure of MCM2-7 double hexamer on dsdna | electron microscopy | 3, B | — | — |
| 5U8S | Structure of eukaryotic cmg helicase at a replication fork | electron microscopy | 3 | ATP | — |
| 5U8T | Structure of eukaryotic cmg helicase at a replication fork and implications | electron microscopy | 3 | ANP | — |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | electron microscopy | 3 | AGS | 4 (best 0.87) |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 | electron microscopy | 3 | AGS | — |
| 5XF8 | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | electron microscopy | 3 | — | 6 (best 0.80) |
| 5XF8 | Cryo-EM structure of the CDT1-MCM2-7 complex in amppnp state | electron microscopy | 3 | — | — |
| 6EYC | Re-refinement of the MCM2-7 double hexamer using isolde | electron microscopy | 3 | ADP | — |
| 6F0L | S. cerevisiae MCM double hexamer bound to duplex DNA | electron microscopy | 3, B | ADP | 10 (best 0.90) |
| 6F0L | S. cerevisiae mcm double hexamer bound to duplex DNA | electron microscopy | 3, B | ADP | — |
| 6HV9 | S. cerevisiae cmg-pol epsilon-DNA | electron microscopy | 3 | AGS | — |
| 6PTJ | Structure of Ctf4 trimer in complex with one CMG helicase | electron microscopy | 3 | — | — |
| 6PTJ | Structure of CTF4 trimer in complex with one cmg helicase | electron microscopy | 3 | — | — |
| 6PTN | Structure of CTF4 trimer in complex with two cmg helicases | electron microscopy | j, 3 | ATP | — |
| 6RQC | Cryo-EM structure of an MCM loading intermediate | electron microscopy | 3 | ADP | 5 (best 0.88) |
| 6SKL | Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1 | electron microscopy | 3 | ANP, MG | 7 (best 0.87) |
| 6SKO | Cryo-EM structure of the fork protection complex bound to cmg at a replication fork - conformation… | electron microscopy | 3 | ANP, MG | — |
| 6U0M | Structure of the S. cerevisiae replicative helicase cmg in complex with a forked DNA | electron microscopy | 3 | ATP | — |
| 6WGC | Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | 3 | — | — |
| 6WGF | Atomic model of mutant MCM2-7 hexamer with MCM6 whd truncation | electron microscopy | 3 | — | — |
| 6WGG | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | electron microscopy | 3 | — | 6 (best 0.85) |
| 6WGG | Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | 3 | — | — |
| 6WGI | Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on DNA at… | electron microscopy | 3 | — | — |
| 7Z13 | S. cerevisiae CMGE dimer nucleating origin DNA melting | electron microscopy | 3, b | ATP, MG | 8 (best 0.87) |
| 8B9B | S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate… | electron microscopy | 3 | ANP, MG | — |
| 8P63 | S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation | electron microscopy | 3 | MG, ATP | 6 (best 0.86) |
| 8W7M | Yeast replisome in state V | electron microscopy | 3 | ADP, MG, AGS | 4 (best 0.85) |
| P24279 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM3 (P24279) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6SKO chain 3 against the predicted model P24279: TM-score 0.97, RMSD 1.42 Å
- 3JC6 chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.25 Å
- 3JC6 chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.25 Å
- 6HV9 chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.71 Å
- 6SKL chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.84 Å
- 7Z13 chain b against the predicted model P24279: TM-score 0.96, RMSD 1.97 Å
- 7Z13 chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.97 Å
- 6PTJ chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.34 Å
- 6PTJ chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.34 Å
- 5U8S chain 3 against the predicted model P24279: TM-score 0.96, RMSD 1.90 Å
Elsewhere
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