UniProt P29496
Minichromosome maintenance protein 5 (P29496)
Minichromosome maintenance protein 5 (UniProt P29496), EC 3.6.4.12: 45 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 129 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P29496
- Protein
- Minichromosome maintenance protein 5
- EC
- 3.6.4.12
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 129 · 20 records with a druggable one
Structures
46 records of P29496 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JA8 | Cryo-EM structure of the MCM2-7 double hexamer | electron microscopy | 5 | — | — |
| 3JA8 | Cryo-EM structure of the MCM2-7 double hexamer | electron microscopy | 5 | — | — |
| 3JC5 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 3JC5 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 3JC6 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 3JC6 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 3JC7 | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 3JC7 | Structure of the eukaryotic replicative cmg helicase and pumpjack motion | electron microscopy | 5 | — | — |
| 5BK4 | Cryo-EM structure of Mcm2-7 double hexamer on dsDNA | electron microscopy | 5, D | ADP | 9 (best 0.87) |
| 5BK4 | Cryo-EM structure of MCM2-7 double hexamer on dsdna | electron microscopy | 5, D | — | — |
| 5U8S | Structure of eukaryotic CMG helicase at a replication fork | electron microscopy | 5 | ATP | 7 (best 0.88) |
| 5U8S | Structure of eukaryotic cmg helicase at a replication fork | electron microscopy | 5 | ATP | — |
| 5U8T | Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications | electron microscopy | 5 | ANP | 6 (best 0.86) |
| 5U8T | Structure of eukaryotic cmg helicase at a replication fork and implications | electron microscopy | 5 | ANP | — |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | electron microscopy | 5 | — | 2 (best 0.79) |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 | electron microscopy | 5 | — | — |
| 5XF8 | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | electron microscopy | 5 | — | 6 (best 0.80) |
| 5XF8 | Cryo-EM structure of the CDT1-MCM2-7 complex in amppnp state | electron microscopy | 5 | — | — |
| 6EYC | Re-refinement of the MCM2-7 double hexamer using ISOLDE | electron microscopy | 5 | ADP, ZN | 7 (best 0.86) |
| 6EYC | Re-refinement of the MCM2-7 double hexamer using isolde | electron microscopy | 5 | ADP, ZN | — |
| 6F0L | S. cerevisiae MCM double hexamer bound to duplex DNA | electron microscopy | 5, D | ADP | 9 (best 0.88) |
| 6F0L | S. cerevisiae mcm double hexamer bound to duplex DNA | electron microscopy | 5, D | ADP | — |
| 6HV9 | S. cerevisiae cmg-pol epsilon-DNA | electron microscopy | 5 | AGS | — |
| 6PTJ | Structure of Ctf4 trimer in complex with one CMG helicase | electron microscopy | 5 | — | — |
| 6PTJ | Structure of CTF4 trimer in complex with one cmg helicase | electron microscopy | 5 | — | — |
| 6PTN | Structure of CTF4 trimer in complex with two cmg helicases | electron microscopy | l, 5 | ATP | — |
| 6RQC | Cryo-EM structure of an MCM loading intermediate | electron microscopy | 5 | ADP, ZN | 7 (best 0.88) |
| 6SKL | Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1 | electron microscopy | 5 | ANP, MG, ZN | 6 (best 0.87) |
| 6SKO | Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation… | electron microscopy | 5 | ANP, MG | 4 (best 0.84) |
| 6SKO | Cryo-EM structure of the fork protection complex bound to cmg at a replication fork - conformation… | electron microscopy | 5 | ANP | — |
| 6U0M | Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | electron microscopy | 5 | ATP | 8 (best 0.86) |
| 6U0M | Structure of the S. cerevisiae replicative helicase cmg in complex with a forked DNA | electron microscopy | 5 | ATP | — |
| 6WGF | Atomic model of mutant MCM2-7 hexamer with MCM6 whd truncation | electron microscopy | 5 | — | — |
| 6WGG | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | electron microscopy | 5 | — | 3 (best 0.85) |
| 6WGG | Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | 5 | — | — |
| 6WGI | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at… | electron microscopy | 5 | — | 4 (best 0.80) |
| 6WGI | Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on DNA at… | electron microscopy | 5 | — | — |
| 7P5Z | Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase | electron microscopy | 5, D | ADP, MG, ZN | 7 (best 0.87) |
| 7PT7 | Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I | electron microscopy | 5, E | ADP, BEF, MG, ZN | 8 (best 0.87) |
| 7V3U | Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD | electron microscopy | 5, E | ADP, MG, AGS, ZN | 9 (best 0.88) |
| 7V3V | Cryo-EM structure of MCM double hexamer bound with DDK in State I | electron microscopy | 5, E | ADP, AGS, MG, ZN | 10 (best 0.88) |
| 8B9B | S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate… | electron microscopy | 5 | ANP, MG, ZN | — |
| 8P63 | S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation | electron microscopy | 5 | MG, ATP, ZN | 7 (best 0.89) |
| 8RIG | Cryo-EM structure of an MCM helicase single hexamer loaded onto dsDNA. | electron microscopy | 5 | ADP, MG, ZN | 6 (best 0.84) |
| 8W7M | Yeast replisome in state V | electron microscopy | 5 | ADP, MG, ZN | 4 (best 0.84) |
| P29496 | AlphaFold monomer V2.0 prediction for minichromosome maintenance protein 5 (P29496) | predicted | A | — | — |
Ligands
- ADP · Adenosine-5'-diphosphate · in 12 records
- ZN · Zinc ion · in 12 records
- MG · Magnesium ion · in 10 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 6 records
- ATP · Adenosine-5'-triphosphate · in 6 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 3 records
- BEF · Beryllium trifluoride ion · in 1 record
Experiment against prediction
- 6PTJ chain 5 against the predicted model P29496: TM-score 0.94, RMSD 1.66 Å
- 6PTJ chain 5 against the predicted model P29496: TM-score 0.94, RMSD 1.66 Å
- 3JC6 chain 5 against the predicted model P29496: TM-score 0.94, RMSD 1.79 Å
- 3JC6 chain 5 against the predicted model P29496: TM-score 0.94, RMSD 1.79 Å
- 6SKO chain 5 against the predicted model P29496: TM-score 0.92, RMSD 1.96 Å
- 6SKO chain 5 against the predicted model P29496: TM-score 0.92, RMSD 1.96 Å
- 6WGI chain 5 against the predicted model P29496: TM-score 0.90, RMSD 2.93 Å
- 6WGI chain 5 against the predicted model P29496: TM-score 0.90, RMSD 2.93 Å
- 5V8F chain 5 against the predicted model P29496: TM-score 0.80, RMSD 4.34 Å
- 5V8F chain 5 against the predicted model P29496: TM-score 0.80, RMSD 4.34 Å
Elsewhere
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