KIF2C-darpin fusion protein bound to tubulin

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · chains A, B
• GDP · Guanosine-5'-diphosphate · ligand · chains B
• LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · ligand · chains A, B
• ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains C
• MG · Magnesium ion · metal · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5MIO · KIF2C-darpin fusion protein bound to tubulin · the same entry in another collection · chain A against A, TM-score 1.00
• Q99661 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF2C (Q99661) · a predicted model of the same protein · chain C against A, TM-score 0.64

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P81947
• Every structure of UniProt D0VWY9
• Every structure of UniProt Q99661
• Elsewhere: RCSB PDB 5MIO · PDBe 5MIO · UniProt P81947 · UniProt D0VWY9 · UniProt Q99661