UniProt D0VWY9

Tubulin beta chain (D0VWY9)

Tubulin beta chain (UniProt D0VWY9): 49 experimental structures on GenesisL1, 9 ligands bound, 63 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: D0VWY9
Protein: Tubulin beta chain
Experimental structures: 49
Predicted models: 0
Ligands: 9
Pockets: 63 · 5 records with a druggable one

Structures

49 records of D0VWY9 in the MolNFT archive: 49 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3N2G	TUBULIN-NSC 613863: RB3 Stathmin-like domain complex	x-ray diffraction	B, D	—	—
3N2G	Tubulin-nsc 613863: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3N2K	TUBULIN-NSC 613862: RB3 Stathmin-like domain complex	x-ray diffraction	B, D	—	—
3N2K	Tubulin-nsc 613862: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYC	Tubulin: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYC	Tubulin: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYF	GTP-Tubulin: RB3 Stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYF	GTP-tubulin: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYH	GMPCPP-Tubulin: RB3 Stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYH	Gmpcpp-tubulin: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYI	GDP-Tubulin: rb3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3RYI	GDP-tubulin: RB3 stathmin-like domain complex	x-ray diffraction	B, D	—	—
3UT5	Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex	x-ray diffraction	B, D	—	—
3UT5	Tubulin-colchicine-ustiloxin: stathmin-like domain complex	x-ray diffraction	B, D	—	—
4DRX	GTP-Tubulin in complex with a DARPIN	x-ray diffraction	B, D	—	—
4DRX	GTP-tubulin in complex with a darpin	x-ray diffraction	B, D	—	—
4EB6	Tubulin-Vinblastine: Stathmin-like complex	x-ray diffraction	B, D	—	—
4EB6	Tubulin-vinblastine: stathmin-like complex	x-ray diffraction	B, D	—	—
4F61	Tubulin:Stathmin-like domain complex	x-ray diffraction	B, D, F, H	—	—
4F61	TUBULIN:STATHMIN-like domain complex	x-ray diffraction	B, D, F, H	—	—
4F6R	Tubulin:Stathmin-like domain complex	x-ray diffraction	B	—	—
4F6R	TUBULIN:STATHMIN-like domain complex	x-ray diffraction	B	—	—
4HNA	Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN	x-ray diffraction	B	—	—
4HNA	Kinesin motor domain in the ADP-mg-alfx state in complex with tubulin and a darpin	x-ray diffraction	B	—	—
4X1I	Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
4X1K	Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	GTP, MG, GDP, LOC, 3WZ	15 (best 0.84)
4X1K	Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
4X1Y	Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
4X1Y	Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
4X20	Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
4X20	Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications	x-ray diffraction	B, D	—	—
5EYP	Tubulin-darpin complex	x-ray diffraction	B	GTP, MG, SO4, GDP, LOC	10 (best 0.83)
5EYP	Tubulin-darpin complex	x-ray diffraction	B	—	—
5KX5	Crystal structure of tubulin-stathmin-TTL-Compound 11 complex	x-ray diffraction	B, D	GTP, GDP, MG, CA, 6YK	—
5KX5	Crystal structure of tubulin-stathmin-ttl-compound 11 complex	x-ray diffraction	B, D	GTP, GDP, MG, CA, 6YK	—
5MIO	KIF2C-darpin fusion protein bound to tubulin	x-ray diffraction	B	GTP, MG, GDP, LOC	10 (best 0.83)
5MIO	KIF2C-darpin fusion protein bound to tubulin	x-ray diffraction	B	GTP, GDP, LOC	—
6GVM	Tubulin:F3II DARPin complex	x-ray diffraction	B	GTP, GDP	—
6GVM	TUBULIN:F3II darpin complex	x-ray diffraction	B	GTP, GDP	—
6GVN	Tubulin:TM-3 DARPin complex	x-ray diffraction	B	GTP, MG	—
6GVN	TUBULIN:TM-3 darpin complex	x-ray diffraction	B	GTP, MG	—
6GWC	Tubulin:iE5 alphaRep complex	x-ray diffraction	B	GTP, MG	—
6GWC	TUBULIN:IE5 alpharep complex	x-ray diffraction	B	GTP, MG	—
6GWD	Tubulin:iiH5 alphaRep complex	x-ray diffraction	B, D, F	GTP, MG, GDP	—
6GWD	TUBULIN:IIH5 alpharep complex	x-ray diffraction	B, D, F	GTP, MG, GDP	—
6GX7	Tubulin-CopN-alphaRep complex	x-ray diffraction	B, D	GTP, MG	—
6GX7	Tubulin-copn-alpharep complex	x-ray diffraction	B, D	GTP, MG	—
8CGZ	tubulin-AB8939 complex	x-ray diffraction	B, D	GTP, GDP, UIY, SO4	12 (best 0.84)
9F07	TUBULIN:STATHMIN:DARPIN:TAU MTBR3 complex	x-ray diffraction	B, F	GTP, MG, GDP	16 (best 0.81)

Ligands

GTP · Guanosine-5'-triphosphate · in 18 records
MG · Magnesium ion · in 14 records
GDP · Guanosine-5'-diphosphate · in 12 records
LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · in 4 records
6YK · (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[[(2~{S},3~{S})-2-[[(2~{R})-1,2-dimethylpyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoyl]-methyl-amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-aminophenyl)-2-methyl-pentanoic acid · in 2 records
CA · Calcium ion · in 2 records
SO4 · Sulfate ion · in 2 records
3WZ · 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 1 record
UIY · Ab-8939 · in 1 record

Elsewhere

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