MolNFT v1 · #113129 · protein
Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution.
5A63: “Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution.”. Electron microscopy. MolNFT v1 #113129 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5A63
- Type
- protein
- Length
- 1,223 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q92542, P49768, Q96BI3, Q9NZ42
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 665 | — | Q92542 |
| B | — | protein | 215 | — | P49768 |
| C | — | protein | 243 | — | Q96BI3 |
| D | — | protein | 100 | — | Q9NZ42 |
Compared structures
- 5A63 · Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. · the same entry in another collection · chain D against D, TM-score 1.00
- Q92542 · AlphaFold monomer V2.0 prediction for nicastrin (Q92542) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q96BI3 · AlphaFold monomer V2.0 prediction for gamma-secretase subunit aph-1A (Q96BI3) · a predicted model of the same protein · chain C against A, TM-score 0.97
- Q9NZ42 · AlphaFold monomer V2.0 prediction for gamma-secretase subunit pen-2 (Q9NZ42) · a predicted model of the same protein · chain D against A, TM-score 0.97
- P49768 · AlphaFold monomer V2.0 prediction for presenilin-1 (P49768) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92542
- Every structure of UniProt P49768
- Every structure of UniProt Q96BI3
- Every structure of UniProt Q9NZ42
- Elsewhere: RCSB PDB 5A63 · PDBe 5A63 · UniProt Q92542 · UniProt P49768 · UniProt Q96BI3 · UniProt Q9NZ42
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