UniProt P49768
Presenilin-1 (P49768)
Presenilin-1 (UniProt P49768), EC 3.4.23.-: 28 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 99 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49768
- Protein
- Presenilin-1
- EC
- 3.4.23.-
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 99 · 13 records with a druggable one
Structures
29 records of P49768 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KR6 | Solution structure of presenilin-1 CTF subunit | solution nmr | A | — | — |
| 2KR6 | Solution structure of presenilin-1 ctf subunit | solution nmr | A | — | — |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | electron microscopy | B | — | — |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution. | electron microscopy | B | — | — |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug DAPT | electron microscopy | B | — | 7 (best 0.81) |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug dapt | electron microscopy | B | — | — |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | B | — | 9 (best 0.72) |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | B | — | — |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | B | — | 9 (best 0.71) |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | B | — | — |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | B | — | 14 (best 0.68) |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | B | — | — |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a Notch fragment | electron microscopy | B | PC1 | 8 (best 0.78) |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a notch fragment | electron microscopy | B | PC1 | — |
| 6IYC | Recognition of the amyloid precursor protein by human gamma-secretase | electron microscopy | B | PC1 | — |
| 6LQG | Human gamma-secretase in complex with small molecule Avagacestat | electron microscopy | B | EN9, PC1 | — |
| 6LQG | Human gamma-secretase in complex with small molecule avagacestat | electron microscopy | B | EN9, PC1 | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | B | PC1, ESF | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | B | PC1, ESF | — |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | B | PC1, FTO | — |
| 7D8X | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | B | PC1, GZR, PTY, FTO | 7 (best 0.81) |
| 7D8X | Cryoem structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | B | PC1, GZR, PTY, FTO | — |
| 7Y5T | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | electron microscopy | B | PC1, IGD | 6 (best 0.83) |
| 8KCP | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | electron microscopy | B | PC1, N9C | 6 (best 0.83) |
| 8KCS | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | electron microscopy | B | PC1, Q70 | 7 (best 0.82) |
| 8X52 | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | electron microscopy | B | PC1 | 8 (best 0.75) |
| 8X53 | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | electron microscopy | B | PC1 | 7 (best 0.75) |
| 8X54 | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | electron microscopy | B | PC1 | 7 (best 0.74) |
| P49768 | AlphaFold monomer V2.0 prediction for presenilin-1 (P49768) | predicted | A | — | 4 (best 0.80) |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 16 records
- FTO · ~{tert}-butyl ~{N}-[(2~{S},3~{R},5~{R})-6-[[(2~{S})-1-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-oxidanyl-6-oxidanylidene-1-phenyl-5-(phenylmethyl) hexan-2-yl]carbamate · in 3 records
- EN9 · (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2, 4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide · in 2 records
- ESF · (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide · in 2 records
- GZR · 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one · in 2 records
- PTY · Phosphatidylethanolamine · in 2 records
- IGD · ~{N}-[4-[2,5-bis(fluoranyl)phenyl]-4-(4-chlorophenyl)sulfonyl-cyclohexyl]-1,1,1-tris(fluoranyl)methanesulfonamide · in 1 record
- N9C · 4,4,4-tris(fluoranyl)-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxidanylidene-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxidanylidene-propan-2-yl]butanamide · in 1 record
- Q70 · Osugacestat · in 1 record
Experiment against prediction
- 8KCP chain B against the predicted model P49768: TM-score 0.98, RMSD 1.00 Å
- 8X53 chain B against the predicted model P49768: TM-score 0.98, RMSD 1.00 Å
- 8X54 chain B against the predicted model P49768: TM-score 0.98, RMSD 1.01 Å
- 8X52 chain B against the predicted model P49768: TM-score 0.98, RMSD 1.01 Å
- 7C9I chain B against the predicted model P49768: TM-score 0.98, RMSD 1.10 Å
- 7D8X chain B against the predicted model P49768: TM-score 0.98, RMSD 1.11 Å
- 7D8X chain B against the predicted model P49768: TM-score 0.98, RMSD 1.11 Å
- 7Y5T chain B against the predicted model P49768: TM-score 0.98, RMSD 1.14 Å
- 6LR4 chain B against the predicted model P49768: TM-score 0.98, RMSD 1.11 Å
- 6LR4 chain B against the predicted model P49768: TM-score 0.98, RMSD 1.11 Å
Elsewhere
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