MolNFT v1 · #42711 · protein

Solution structure of presenilin-1 ctf subunit

2KR6: “Solution structure of presenilin-1 ctf subunit”. Solution nmr, 2 pockets (best druggability 0.63). MolNFT v1 #42711 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KR6
Type: protein
Length: 176 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Presenilin-1
EC: 3.4.23.-
UniProt: P49768
Pockets: 2 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 38% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Presenilin-1 (EC 3.4.23.-)	protein	176	38% helix, 0% strand	P49768

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.63	0.89	16	empty
2	125	0.45	0.77	23	empty

Compared structures

2KR6 · Solution structure of presenilin-1 CTF subunit · the same entry in another collection · chain A against A, TM-score 1.00
P49768 · AlphaFold monomer V2.0 prediction for presenilin-1 (P49768) · a predicted model of the same protein · chain A against A, TM-score 0.37

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49768
Elsewhere: RCSB PDB 2KR6 · PDBe 2KR6 · UniProt P49768

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