FTO · ~{tert}-butyl ~{N}-[(2~{S},3~{R},5~{R})-6-[[(2~{S})-1-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-oxidanyl-6-oxidanylidene-1-phenyl-5-(phenylmethyl) hexan-2-yl]carbamate

Binding sites

FTO in 4 structures; the first of them:

• 7C9I · Human gamma-secretase in complex with small molecule L-685,458 · FTO B502 · binds ILE143, ASP257, VAL261, LEU268, LEU271, VAL272, LEU286, ILE287 and 16 more
• 7D8X · CryoEM structure of human gamma-secretase in complex with E2012 and L685458 · FTO B504 · binds TYR77, LEU85, ILE143, ILE253, ASP257, VAL261, LEU268, LEU271 and 21 more
• 7C9I · Human gamma-secretase in complex with small molecule L-685,458 · FTO B502 · binds ASP257, LEU268, VAL272, LEU286, VAL379, LYS380, LEU381, GLY382 and 9 more
• 7D8X · Cryoem structure of human gamma-secretase in complex with E2012 and L685458 · FTO B504 · binds TYR77, LEU85, ASP257, LEU268, LEU271, VAL272, LEU286, ILE287 and 13 more

Residues it binds most

LEU 4, VAL 4, ASP 4, GLY 4, ALA 4, ILE 3, LYS 4, THR 4, PHE 3, PRO 2 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine
• BMA · beta-D-mannopyranose
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• GZR · 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one
• PTY · Phosphatidylethanolamine