UniProt Q96BI3
Gamma-secretase subunit APH-1A (Q96BI3)
Gamma-secretase subunit APH-1A (UniProt Q96BI3): 35 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 162 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96BI3
- Protein
- Gamma-secretase subunit APH-1A
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 162 · 29 records with a druggable one
Structures
36 records of Q96BI3 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | electron microscopy | C | NAG, PC1 | 5 (best 0.70) |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution. | electron microscopy | C | NAG, PC1 | 5 (best 0.70) |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug DAPT | electron microscopy | C | — | 5 (best 0.70) |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug dapt | electron microscopy | C | — | 5 (best 0.70) |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | C | — | 4 (best 0.70) |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | C | — | 4 (best 0.70) |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | C | — | 6 (best 0.71) |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | C | — | 6 (best 0.71) |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | C | — | 7 (best 0.69) |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | C | — | 7 (best 0.69) |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a Notch fragment | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.72) |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a notch fragment | electron microscopy | C | NAG, PC1, CLR | — |
| 6IYC | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.74) |
| 6IYC | Recognition of the amyloid precursor protein by human gamma-secretase | electron microscopy | C | NAG, PC1, CLR | — |
| 6LQG | Human gamma-secretase in complex with small molecule Avagacestat | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.70) |
| 6LQG | Human gamma-secretase in complex with small molecule avagacestat | electron microscopy | C | NAG, PC1, CLR | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.73) |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | C | PC1, CLR | — |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | C | NAG, PC1, CLR | 5 (best 0.75) |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | C | PC1, CLR | — |
| 7D8X | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | C | NAG, PC1, CLR | 5 (best 0.75) |
| 7D8X | Cryoem structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | C | PC1, CLR | — |
| 7Y5T | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | electron microscopy | C | NAG, PC1, CLR | 4 (best 0.70) |
| 7Y5X | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | electron microscopy | C | PC1, CLR | 5 (best 0.70) |
| 7Y5Z | CryoEM structure of human PS2-containing gamma-secretase | electron microscopy | C | PC1, CLR | 6 (best 0.71) |
| 8IM7 | Human gamma-secretase treated with ganglioside GM1 | electron microscopy | C | NAG, PC1, CLR | 5 (best 0.70) |
| 8K8E | Human gamma-secretase in complex with a substrate mimetic | electron microscopy | C | PC1, CLR | 6 (best 0.71) |
| 8KCO | Cryo-EM structure of human gamma-secretase in complex with RO4929097 | electron microscopy | C | NAG, PC1, CLR | 5 (best 0.70) |
| 8KCP | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.75) |
| 8KCS | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.72) |
| 8KCT | Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | electron microscopy | C | NAG, CLR, PC1 | 6 (best 0.75) |
| 8KCU | Cryo-EM structure of human gamma-secretase in complex with MK-0752 | electron microscopy | C | NAG, PC1, CLR | 7 (best 0.77) |
| 8X52 | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | electron microscopy | C | NAG, PC1, CLR | 6 (best 0.75) |
| 8X53 | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | electron microscopy | C | NAG, PC1, CLR | 7 (best 0.75) |
| 8X54 | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | electron microscopy | C | NAG, PC1, CLR | 5 (best 0.74) |
| Q96BI3 | AlphaFold monomer V2.0 prediction for gamma-secretase subunit aph-1A (Q96BI3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5A63 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.02 Å
- 5A63 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.02 Å
- 8KCS chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.02 Å
- 5FN3 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.05 Å
- 5FN3 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.05 Å
- 7D8X chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.07 Å
- 7D8X chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.07 Å
- 5FN2 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.04 Å
- 5FN2 chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.04 Å
- 8K8E chain C against the predicted model Q96BI3: TM-score 0.97, RMSD 1.09 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.