UniProt Q92542
Nicastrin (Q92542)
Nicastrin (UniProt Q92542): 38 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 222 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92542
- Protein
- Nicastrin
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 222 · 21 records with a druggable one
Structures
39 records of Q92542 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N7Q | Structure of the transmembrane domain of human nicastrin in SDS micelles | solution nmr | A | — | — |
| 2N7Q | Structure of the transmembrane domain of human nicastrin in sds micelles | solution nmr | A | — | — |
| 2N7R | Structure of the transmembrane domain of human nicastrin in DPC micelles | solution nmr | A | — | — |
| 2N7R | Structure of the transmembrane domain of human nicastrin in dpc micelles | solution nmr | A | — | — |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | electron microscopy | A | — | — |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution. | electron microscopy | A | — | — |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug DAPT | electron microscopy | A | — | 8 (best 0.66) |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug dapt | electron microscopy | A | — | — |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | A | — | 10 (best 0.70) |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | A | — | — |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | A | — | 11 (best 0.71) |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | A | — | — |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | A | — | 10 (best 0.69) |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | A | — | — |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a Notch fragment | electron microscopy | A | NAG, BMA, PC1 | 14 (best 0.78) |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a notch fragment | electron microscopy | A | NAG, PC1 | — |
| 6IYC | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | electron microscopy | A | NAG, BMA, PC1 | 11 (best 0.74) |
| 6IYC | Recognition of the amyloid precursor protein by human gamma-secretase | electron microscopy | A | NAG, PC1 | — |
| 6LQG | Human gamma-secretase in complex with small molecule Avagacestat | electron microscopy | A | NAG, BMA, PC1 | — |
| 6LQG | Human gamma-secretase in complex with small molecule avagacestat | electron microscopy | A | NAG, BMA, PC1 | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | A | NAG, BMA, PC1 | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | A | NAG, BMA, PC1 | — |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | A | NAG, BMA, PC1 | — |
| 7D8X | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | A | NAG, BMA, GZR, PC1 | 12 (best 0.75) |
| 7D8X | Cryoem structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | A | NAG, GZR, PC1 | — |
| 7Y5T | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | electron microscopy | A | NAG, BMA, PC1 | 9 (best 0.73) |
| 7Y5X | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | electron microscopy | A | NAG, BMA, PC1 | 10 (best 0.73) |
| 7Y5Z | CryoEM structure of human PS2-containing gamma-secretase | electron microscopy | A | NAG, BMA | 11 (best 0.73) |
| 8K8E | Human gamma-secretase in complex with a substrate mimetic | electron microscopy | A | NAG, BMA | 11 (best 0.71) |
| 8KCO | Cryo-EM structure of human gamma-secretase in complex with RO4929097 | electron microscopy | A | NAG, BMA, PC1 | 10 (best 0.71) |
| 8KCP | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | electron microscopy | A | NAG, BMA, PC1 | 10 (best 0.75) |
| 8KCS | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | electron microscopy | A | NAG, BMA, PC1 | 11 (best 0.72) |
| 8KCT | Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | electron microscopy | A | NAG, BMA, PC1 | 10 (best 0.75) |
| 8KCU | Cryo-EM structure of human gamma-secretase in complex with MK-0752 | electron microscopy | A | NAG, BMA, PC1 | 12 (best 0.77) |
| 8OQY | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid… | electron microscopy | A | NAG, PC1 | 13 (best 0.74) |
| 8X52 | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | electron microscopy | A | NAG, BMA, PC1 | 12 (best 0.75) |
| 8X53 | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | electron microscopy | A | NAG, BMA, PC1 | 12 (best 0.75) |
| 8X54 | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | electron microscopy | A | NAG, BMA, PC1 | 10 (best 0.74) |
| Q92542 | AlphaFold monomer V2.0 prediction for nicastrin (Q92542) | predicted | A | — | 5 (best 0.72) |
Ligands
Experiment against prediction
- 5FN3 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.31 Å
- 5FN3 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.31 Å
- 5A63 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.35 Å
- 5A63 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.35 Å
- 5FN2 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.36 Å
- 5FN2 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.36 Å
- 5FN5 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.38 Å
- 5FN5 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.38 Å
- 5FN4 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.38 Å
- 5FN4 chain A against the predicted model Q92542: TM-score 0.98, RMSD 1.38 Å
Elsewhere
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