UniProt Q9NZ42
Gamma-secretase subunit PEN-2 (Q9NZ42)
Gamma-secretase subunit PEN-2 (UniProt Q9NZ42): 37 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NZ42
- Protein
- Gamma-secretase subunit PEN-2
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 62 · 22 records with a druggable one
Structures
38 records of Q9NZ42 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | electron microscopy | D | — | — |
| 5A63 | Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution. | electron microscopy | D | — | — |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug DAPT | electron microscopy | D | — | 4 (best 0.53) |
| 5FN2 | Cryo-EM structure of gamma secretase in complex with a drug dapt | electron microscopy | D | — | — |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | D | — | 4 (best 0.48) |
| 5FN3 | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | electron microscopy | D | — | — |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | D | — | 3 (best 0.51) |
| 5FN4 | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | electron microscopy | D | — | — |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | D | — | 5 (best 0.58) |
| 5FN5 | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | electron microscopy | D | — | — |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a Notch fragment | electron microscopy | D | PC1 | 4 (best 0.78) |
| 6IDF | Cryo-EM structure of gamma secretase in complex with a notch fragment | electron microscopy | D | PC1 | — |
| 6IYC | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | electron microscopy | D | — | 3 (best 0.74) |
| 6IYC | Recognition of the amyloid precursor protein by human gamma-secretase | electron microscopy | D | — | — |
| 6LQG | Human gamma-secretase in complex with small molecule Avagacestat | electron microscopy | D | — | — |
| 6LQG | Human gamma-secretase in complex with small molecule avagacestat | electron microscopy | D | — | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | D | — | — |
| 6LR4 | Molecular basis for inhibition of human gamma-secretase by small molecule | electron microscopy | D | — | — |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | D | — | 2 (best 0.56) |
| 7C9I | Human gamma-secretase in complex with small molecule L-685,458 | electron microscopy | D | — | — |
| 7D8X | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | D | — | 2 (best 0.57) |
| 7D8X | Cryoem structure of human gamma-secretase in complex with E2012 and L685458 | electron microscopy | D | — | — |
| 7Y5T | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | electron microscopy | D | — | 2 (best 0.58) |
| 7Y5X | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | electron microscopy | D | — | 2 (best 0.53) |
| 7Y5Z | CryoEM structure of human PS2-containing gamma-secretase | electron microscopy | D | — | 4 (best 0.58) |
| 8IM7 | Human gamma-secretase treated with ganglioside GM1 | electron microscopy | D | — | 2 (best 0.58) |
| 8K8E | Human gamma-secretase in complex with a substrate mimetic | electron microscopy | D | — | 2 (best 0.51) |
| 8KCO | Cryo-EM structure of human gamma-secretase in complex with RO4929097 | electron microscopy | D | — | 2 (best 0.55) |
| 8KCP | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | electron microscopy | D | — | 2 (best 0.56) |
| 8KCS | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | electron microscopy | D | — | 2 (best 0.57) |
| 8KCT | Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | electron microscopy | D | — | 2 (best 0.56) |
| 8KCU | Cryo-EM structure of human gamma-secretase in complex with MK-0752 | electron microscopy | D | — | 2 (best 0.55) |
| 8OQY | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid… | electron microscopy | D | — | 3 (best 0.68) |
| 8OQZ | Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in… | electron microscopy | D | PC1 | 3 (best 0.64) |
| 8X52 | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | electron microscopy | D | — | 3 (best 0.62) |
| 8X53 | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | electron microscopy | D | — | 2 (best 0.64) |
| 8X54 | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | electron microscopy | D | — | 2 (best 0.56) |
| Q9NZ42 | AlphaFold monomer V2.0 prediction for gamma-secretase subunit pen-2 (Q9NZ42) | predicted | A | — | — |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 3 records
Experiment against prediction
- 7D8X chain D against the predicted model Q9NZ42: TM-score 0.99, RMSD 0.43 Å
- 7D8X chain D against the predicted model Q9NZ42: TM-score 0.99, RMSD 0.43 Å
- 8KCS chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.52 Å
- 8KCT chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8X53 chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8KCU chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8X52 chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8KCP chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8X54 chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.57 Å
- 8KCO chain D against the predicted model Q9NZ42: TM-score 0.98, RMSD 0.58 Å
Elsewhere
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