Research workbench
Ferric hydroxamate uptake receptor (fhua) from E.COLI
Analyse Ferric hydroxamate uptake receptor (fhua) from E.COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FCP
- Type
- protein
- Length
- 705 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (ferric hydroxamate uptake receptor)
- UniProt
- P06971
- Ligands
- LIL, AAE, LIM, EA2, GP1, GP4, GPH, KDO, GLA, GMH, GLC, NI
- Pockets
- 6 · best druggability 0.89
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (ferric hydroxamate uptake receptor) | protein | 705 | 7% helix, 56% strand | P06971 |
Ligands and binding sites
- LIL · 2-tridecanoyloxy-pentadecanoic acid · ligand · 2 copies · chains A
- AAE · Acetoacetic acid · ligand
- LIM · 3-oxo-pentadecanoic acid · ligand · chains A
- EA2 · Aminoethanolpyrophosphate · ligand
- GP1 · 2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose · ligand · chains A
- GP4 · 2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose · ligand · chains A
- GPH · 4-O-phosphono-D-glycero-beta-D-manno-heptopyranose · ligand
- KDO · 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid · sugar · 2 copies · chains A
- GLA · alpha-D-galactopyranose · sugar · 2 copies
- GMH · L-glycero-alpha-D-manno-heptopyranose · sugar · chains A
- GLC · alpha-D-glucopyranose · sugar
- NI · Nickel (II) ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 905 | 0.89 | 0.91 | 152 | empty |
| 2 | 51 | 0.72 | 0.99 | 26 | empty |
| 3 | 179 | 0.69 | 0.88 | 36 | empty |
| 4 | 276 | 0.67 | 0.83 | 31 | empty |
| 5 | 412 | 0.64 | 0.79 | 37 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2FCP · Ferric hydroxamate uptake receptor (fhua) from E.COLI · the same entry in another collection · chain A against A, TM-score 1.00
- P06971 · AlphaFold monomer V2.0 prediction for ferrichrome outer membrane TRANSPORTER/PHAGE… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06971
- Elsewhere: RCSB PDB 2FCP · PDBe 2FCP · UniProt P06971
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.