Research workbench
Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution
Analyse Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C9W
- Type
- protein
- Length
- 336 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of cytokine signaling 2; Transcription elongation factor B polypeptide 2…
- UniProt
- O14508, Q15370, Q15369
- Ligands
- NI, SO4
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 2 | protein | 153 | 38% helix, 19% strand | O14508 |
| B | Transcription elongation factor B polypeptide 2 | protein | 103 | 21% helix, 37% strand | Q15370 |
| C | Transcription elongation factor B polypeptide 1 | protein | 80 | 49% helix, 16% strand | Q15369 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.52 | 0.79 | 25 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1151 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 906 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 205 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2C9W · Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O14508 · AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 2 (O14508) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14508
- Every structure of UniProt Q15370
- Every structure of UniProt Q15369
- Elsewhere: RCSB PDB 2C9W · PDBe 2C9W · UniProt O14508 · UniProt Q15370 · UniProt Q15369
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