UniProt O14508
Suppressor of cytokine signaling 2 (O14508)
Suppressor of cytokine signaling 2 (UniProt O14508): 17 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14508
- Protein
- Suppressor of cytokine signaling 2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 23 · 6 records with a druggable one
Structures
18 records of O14508 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2C9W | Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution | x-ray diffraction | A | — | — |
| 2C9W | Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution | x-ray diffraction | A | — | — |
| 4JGH | Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5 | x-ray diffraction | A | — | — |
| 4JGH | Structure of the SOCS2-elongin bc complex bound to an N-terminal fragment of CULLIN5 | x-ray diffraction | A | — | — |
| 5BO4 | Structure of SOCS2:ELONGIN C:ELONGIN B from dmso-treated crystals | x-ray diffraction | A, D, G, J, M, P | — | — |
| 6I4X | Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide | x-ray diffraction | A | — | — |
| 6I4X | Crystal structure of SOCS2:ELONGIN C:ELONGIN B in complex with erythropoietin receptor peptide | x-ray diffraction | A | — | — |
| 6I5J | Crystal structure of SOCS2:ELONGIN C:ELONGIN B in complex with growth hormone receptor peptide | x-ray diffraction | A, D | CO | — |
| 6I5N | Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide | x-ray diffraction | A, D | CO, SO4 | — |
| 6I5N | Crystal structure of SOCS2:ELONGIN C:ELONGIN B in complex with growth hormone receptor peptide | x-ray diffraction | A, D | CO, SO4 | — |
| 7M6T | Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances… | x-ray diffraction | A | SO4 | 1 (best 0.52) |
| 7M6T | Crystal structure of SOCS2/ELONGINB/ELONGINC bound to a non-canonical peptide that enhances… | x-ray diffraction | A | SO4 | — |
| 7ZLM | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551 | x-ray diffraction | A, D, G, J | JIH | 7 (best 0.66) |
| 7ZLN | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11 | x-ray diffraction | A | JI9 | 3 (best 0.54) |
| 7ZLP | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 | x-ray diffraction | A | JHR, PO4 | 2 (best 0.54) |
| 7ZLR | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | x-ray diffraction | A | JH9 | 2 (best 0.49) |
| 7ZLS | co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | x-ray diffraction | A, D, J, G | JH9 | 6 (best 0.75) |
| O14508 | AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 2 (O14508) | predicted | A | — | 2 (best 0.57) |
Ligands
- SO4 · Sulfate ion · in 4 records
- CO · Cobalt (II) ion · in 3 records
- JH9 · [4-[(2~{S})-3-[(4-fluoranyl-3-prop-2-enyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate · in 2 records
- JHR · [4-[(2~{S})-2-[2-(4-fluorophenyl)ethanoylamino]-3-[(4-fluorophenyl)methylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate · in 1 record
- JI9 · [4-[(2~{S})-3-[(4-fluoranyl-3-methyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate · in 1 record
- JIH · [4-[(2~{S})-3-[[3-(2-chloranylethanoylamino)phenyl]methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 2C9W chain A against the predicted model O14508: TM-score 0.99, RMSD 0.59 Å
- 2C9W chain A against the predicted model O14508: TM-score 0.99, RMSD 0.59 Å
- 5BO4 chain A against the predicted model O14508: TM-score 0.98, RMSD 0.62 Å
- 7M6T chain A against the predicted model O14508: TM-score 0.98, RMSD 0.70 Å
- 7M6T chain A against the predicted model O14508: TM-score 0.98, RMSD 0.70 Å
- 5BO4 chain M against the predicted model O14508: TM-score 0.98, RMSD 0.74 Å
- 7ZLS chain D against the predicted model O14508: TM-score 0.97, RMSD 1.04 Å
- 7ZLM chain G against the predicted model O14508: TM-score 0.96, RMSD 1.13 Å
- 7ZLM chain A against the predicted model O14508: TM-score 0.96, RMSD 1.15 Å
- 7ZLM chain D against the predicted model O14508: TM-score 0.96, RMSD 1.27 Å
Elsewhere
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