MolNFT v1 · #432172 · protein
AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 2 (O14508)
O14508: “AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 2 (O14508)”. 2 pockets (best druggability 0.57). MolNFT v1 #432172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O14508
- Type
- protein
- Length
- 198 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbDA05C32aD6eE153C8C5A78dfa48d7Ba25694fea
- Molecule
- Suppressor of cytokine signaling 2
- UniProt
- O14508
- Pockets
- 2 · best druggability 0.57
Structure
1 distinct chain · 31% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 2 | protein | 198 | 31% helix, 16% strand | O14508 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.57 | 0.78 | 23 | empty |
| 2 | 70 | 0.32 | 0.74 | 17 | empty |
Compared structures
- 7ZLO · Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 12 · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7ZLR · Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7ZLP · Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7ZLN · Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11 · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7ZLS · co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 · an experimental structure of the same protein · chain A against J, TM-score 0.78
- 5BO4 · Structure of SOCS2:ELONGIN C:ELONGIN B from dmso-treated crystals · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7M6T · Crystal structure of SOCS2/ELONGINB/ELONGINC bound to a non-canonical peptide that… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7M6T · Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 6I5J · Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 6I5J · Crystal structure of SOCS2:ELONGIN C:ELONGIN B in complex with growth hormone receptor… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 2C9W · Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution · an experimental structure of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14508
- Elsewhere: UniProt O14508 · AlphaFold DB O14508
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