Research workbench
Serotonin 4 (5-HT4) receptor-gs complex
Analyse Serotonin 4 (5-HT4) receptor-gs complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XT9
- Type
- protein
- Length
- 927 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, Q13639
- Ligands
- CLR, PLM, SRO
- Pockets
- 12 · best druggability 0.81
Structure
electron microscopy · 4 distinct chains · 44% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 238 | 47% helix, 16% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 46% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 56% helix, 0% strand | P59768 |
| R | Soluble cytochrome B562,5-hydroxytryptamine receptor 4 | protein | 294 | 82% helix, 1% strand | Q13639 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 4 copies · chains R
- PLM · Palmitic acid · ligand · 2 copies · chains R
- SRO · Serotonin · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 404 | 0.81 | 0.89 | 41 | SRO |
| 2 | 620 | 0.80 | 0.86 | 61 | empty |
| 3 | 1025 | 0.77 | 0.79 | 79 | empty |
| 4 | 114 | 0.54 | 0.83 | 24 | empty |
| 5 | 284 | 0.53 | 0.75 | 36 | empty |
Interfaces
4 interfaces between chains.
- B–G · 2200 Ų buried · 18 hydrogen bonds · protein-protein
- A–R · 1590 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1434 Ų buried · 17 hydrogen bonds · protein-protein
- B–R · 128 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7XT9 · Serotonin 4 (5-HT4) receptor-Gs complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
- Q13639 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 4 (Q13639) · a predicted model of the same protein · chain R against A, TM-score 0.91
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt Q13639
- Elsewhere: RCSB PDB 7XT9 · PDBe 7XT9 · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt Q13639
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