Research workbench
Cryo-EM structure of human galanin receptor 2
Analyse Cryo-EM structure of human galanin receptor 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XBD
- Type
- protein
- Length
- 1,153 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galanin receptor type 2; Guanine nucleotide-binding protein G(Q) subunit alpha; Guanine…
- UniProt
- O43603, P62873, P59768, P22466
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galanin receptor type 2 | protein | 277 | 69% helix, 2% strand | O43603 |
| B | Guanine nucleotide-binding protein G(Q) subunit alpha | protein | 229 | 44% helix, 12% strand | — |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 339 | 8% helix, 41% strand | P62873 |
| D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 59 | 47% helix, 0% strand | P59768 |
| E | SCFV16 | protein | 233 | 3% helix, 41% strand | — |
| F | Galanin | protein | 16 | 44% helix, 0% strand | P22466 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 871 | 0.82 | 0.84 | 67 | empty |
| 2 | 159 | 0.81 | 0.97 | 27 | empty |
| 3 | 902 | 0.70 | 0.75 | 69 | empty |
| 4 | 484 | 0.67 | 0.79 | 63 | empty |
| 5 | 369 | 0.64 | 0.79 | 47 | empty |
Interfaces
7 interfaces between chains.
- C–D · 2182 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1223 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1170 Ų buried · 9 hydrogen bonds · protein-protein
- A–F · 924 Ų buried · 8 hydrogen bonds · protein-protein
- B–E · 586 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7XBD · Cryo-EM structure of human galanin receptor 2 · the same entry in another collection · chain F against F, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
- O43603 · AlphaFold monomer V2.0 prediction for galanin receptor type 2 (O43603) · a predicted model of the same protein · chain A against A, TM-score 0.90
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.81
- P22466 · AlphaFold monomer V2.0 prediction for galanin peptides (P22466) · a predicted model of the same protein · chain F against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43603
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P22466
- Elsewhere: RCSB PDB 7XBD · PDBe 7XBD · UniProt O43603 · UniProt P62873 · UniProt P59768 · UniProt P22466
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