Research workbench
Structure of somatostatin receptor 2 bound with octreotide.
Analyse Structure of somatostatin receptor 2 bound with octreotide. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XAU
- Type
- protein
- Length
- 1,143 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Somatostatin receptor type 2,LARGEBIT; Guanine nucleotide-binding protein G(I) subunit…
- UniProt
- P30874, P63096, P62871, P63212
- Pockets
- 13 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 27% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Somatostatin receptor type 2,LARGEBIT | protein | 281 | 62% helix, 1% strand | P30874 |
| B | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 222 | 33% helix, 15% strand | P63096 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 342 | 7% helix, 46% strand | P62871 |
| D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 58 | 48% helix, 0% strand | P63212 |
| E | SCFV16 | protein | 233 | 3% helix, 44% strand | — |
| F | Octreotide | protein | 7 | 0% helix, 29% strand | — |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 705 | 0.81 | 0.85 | 61 | empty |
| 2 | 908 | 0.71 | 0.76 | 70 | empty |
| 3 | 156 | 0.60 | 0.84 | 33 | empty |
| 4 | 177 | 0.60 | 0.83 | 29 | empty |
| 5 | 171 | 0.55 | 0.80 | 31 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2334 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 1125 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 994 Ų buried · 7 hydrogen bonds · protein-protein
- A–F · 780 Ų buried · 4 hydrogen bonds · protein-protein
- B–E · 555 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 d-amino (disulfide, D-amino acid).
Compared structures
- 7XAU · Structure of somatostatin receptor 2 bound with octreotide. · the same entry in another collection · chain F against F, TM-score 1.00
- P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.98
- P30874 · AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) · a predicted model of the same protein · chain A against A, TM-score 0.87
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.83
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30874
- Every structure of UniProt P63096
- Every structure of UniProt P62871
- Every structure of UniProt P63212
- Elsewhere: RCSB PDB 7XAU · PDBe 7XAU · UniProt P30874 · UniProt P63096 · UniProt P62871 · UniProt P63212
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