Cryo-EM structure of a class a orphan GPCR

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · chains A
• 7ZQ · 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide · ligand · chains R
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.94
• P09850 · AlphaFold monomer V2.0 prediction for endo-1,4-beta-xylanase (P09850) · a predicted model of the same protein · chain R against A, TM-score 0.20

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P09850
• Every structure of UniProt Q6DWJ6
• Elsewhere: RCSB PDB 7VUJ · PDBe 7VUJ · UniProt P62873 · UniProt P59768 · UniProt P09850 · UniProt Q6DWJ6