Cryo-EM structure of a class a orphan GPCR in complex with gi

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• 7ZQ · 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7VUG · Cryo-EM structure of a class A orphan GPCR in complex with Gi · the same entry in another collection · chain S against S, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.96
• Q6DWJ6 · AlphaFold monomer V2.0 prediction for probable G-protein coupled receptor 139 (Q6DWJ6) · a predicted model of the same protein · chain R against A, TM-score 0.88
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
• P09850 · AlphaFold monomer V2.0 prediction for endo-1,4-beta-xylanase (P09850) · a predicted model of the same protein · chain R against A, TM-score 0.21

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P09850
• Every structure of UniProt Q6DWJ6
• Elsewhere: RCSB PDB 7VUG · PDBe 7VUG · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P09850 · UniProt Q6DWJ6