Research workbench
EIF2B-sfsv nss C2-imposed
Analyse EIF2B-sfsv nss C2-imposed in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VLK
- Type
- protein
- Length
- 3,698 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor eif-2B subunit alpha; Translation initiation factor eif-2B…
- UniProt
- Q14232, P49770, Q9NR50, Q9UI10, Q13144, P12792
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 6 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Translation initiation factor eif-2B subunit alpha | protein | 294 | 53% helix, 14% strand | Q14232 |
| C, D | Translation initiation factor eif-2B subunit beta | protein | 333 | 52% helix, 14% strand | P49770 |
| E, F | Translation initiation factor eif-2B subunit gamma | protein | 242 | 33% helix, 26% strand | Q9NR50 |
| G, H | Translation initiation factor eif-2B subunit delta | protein | 356 | 48% helix, 15% strand | Q9UI10 |
| I, J | Translation initiation factor eif-2B subunit epsilon | protein | 427 | 22% helix, 28% strand | Q13144 |
| K, L | Non-structural protein ns-S | protein | 197 | 37% helix, 17% strand | P12792 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 949 | 0.85 | 0.87 | 100 | empty |
| 2 | 764 | 0.84 | 0.87 | 85 | empty |
| 3 | 1031 | 0.80 | 0.81 | 87 | empty |
| 4 | 980 | 0.80 | 0.81 | 87 | empty |
| 5 | 1195 | 0.76 | 0.78 | 110 | empty |
Interfaces
26 interfaces between chains.
- D–G · 2082 Ų buried · 24 hydrogen bonds · protein-protein
- C–H · 2064 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1556 Ų buried · 23 hydrogen bonds · protein-protein
- D–I · 1327 Ų buried · 14 hydrogen bonds · protein-protein
- C–J · 1301 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7VLK · eIF2B-SFSV NSs C2-imposed · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14232
- Every structure of UniProt P49770
- Every structure of UniProt Q9NR50
- Every structure of UniProt Q9UI10
- Every structure of UniProt Q13144
- Every structure of UniProt P12792
- Elsewhere: RCSB PDB 7VLK · PDBe 7VLK · UniProt Q14232 · UniProt P49770 · UniProt Q9NR50 · UniProt Q9UI10 · UniProt Q13144 · UniProt P12792
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.