Research workbench
Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in complex with a viral protein nss
Analyse Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RLO
- Type
- protein
- Length
- 3,670 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor eif-2B subunit epsilon; Translation initiation factor…
- UniProt
- Q13144, P49770, Q9UI10, Q14232, Q9NR50, P12792
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 7 distinct chains · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Translation initiation factor eif-2B subunit epsilon | protein | 414 | 21% helix, 29% strand | Q13144 |
| C, D | Translation initiation factor eif-2B subunit beta | protein | 333 | 48% helix, 14% strand | P49770 |
| E, F | Translation initiation factor eif-2B subunit delta | protein | 353 | 43% helix, 14% strand | Q9UI10 |
| G, H | Translation initiation factor eif-2B subunit alpha | protein | 284 | 49% helix, 14% strand | Q14232 |
| I | Translation initiation factor eif-2B subunit gamma | protein | 238 | 31% helix, 28% strand | Q9NR50 |
| J | Translation initiation factor eif-2B subunit gamma | protein | 228 | 26% helix, 27% strand | Q9NR50 |
| K, L | Non-structural protein ns-S | protein | 218 | 38% helix, 12% strand | P12792 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1092 | 0.86 | 0.88 | 145 | empty |
| 2 | 966 | 0.83 | 0.84 | 122 | empty |
| 3 | 703 | 0.83 | 0.86 | 84 | empty |
| 4 | 1016 | 0.79 | 0.80 | 86 | empty |
| 5 | 662 | 0.79 | 0.84 | 85 | empty |
Interfaces
25 interfaces between chains.
- C–F · 2154 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 2146 Ų buried · 20 hydrogen bonds · protein-protein
- G–H · 1293 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1228 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 1207 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7RLO · Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13144
- Every structure of UniProt P49770
- Every structure of UniProt Q9UI10
- Every structure of UniProt Q14232
- Every structure of UniProt Q9NR50
- Every structure of UniProt P12792
- Elsewhere: RCSB PDB 7RLO · PDBe 7RLO · UniProt Q13144 · UniProt P49770 · UniProt Q9UI10 · UniProt Q14232 · UniProt Q9NR50 · UniProt P12792
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