Research workbench
Nucleosome stack of the 4X197 nucleosome array containing H1
Analyse Nucleosome stack of the 4X197 nucleosome array containing H1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PFC
- Type
- protein + DNA
- Length
- 2,299 residues
- Chains
- 19
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3.2; Histone H4; Histone H2A type 1-B/E; Histone H2B type 1-K; DNA (788-mer)…
- UniProt
- Q71DI3, P62805, P04908, O60814, P10412
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 7 distinct chains · 59% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, K, O | Histone H3.2 | protein | 97 | 66% helix, 4% strand | Q71DI3 |
| B, F, L, P | Histone H4 | protein | 83 | 57% helix, 6% strand | P62805 |
| C, G, M, Q | Histone H2A type 1-B/E | protein | 109 | 50% helix, 6% strand | P04908 |
| D, H, N, R | Histone H2B type 1-K | protein | 95 | 73% helix, 4% strand | O60814 |
| J | DNA (788-mer) | dna | 344 | — | — |
| I | DNA (788-mer) | dna | 344 | — | — |
| U | Histone H1.4 | protein | 75 | 47% helix, 8% strand | P10412 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 768 | 0.84 | 0.87 | 85 | empty |
| 2 | 375 | 0.77 | 0.88 | 36 | empty |
| 3 | 632 | 0.77 | 0.83 | 67 | empty |
| 4 | 71 | 0.76 | 0.98 | 22 | empty |
| 5 | 67 | 0.75 | 0.99 | 20 | empty |
Interfaces
77 interfaces between chains.
- J–I · 15914 Ų buried · 1,598 hydrogen bonds · nucleic-nucleic
- G–H · 2632 Ų buried · 29 hydrogen bonds · protein-protein
- Q–R · 2629 Ų buried · 31 hydrogen bonds · protein-protein
- M–N · 2607 Ų buried · 32 hydrogen bonds · protein-protein
- K–L · 2557 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 7PFC · Nucleosome stack of the 4x197 nucleosome array containing H1 · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71DI3
- Every structure of UniProt P62805
- Every structure of UniProt P04908
- Every structure of UniProt O60814
- Every structure of UniProt P10412
- Elsewhere: RCSB PDB 7PFC · PDBe 7PFC · UniProt Q71DI3 · UniProt P62805 · UniProt P04908 · UniProt O60814 · UniProt P10412
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.