UniProt P10412
Histone H1.4 (P10412)
Histone H1.4 (UniProt P10412): 45 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P10412
- Protein
- Histone H1.4
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 12 records with a druggable one
Structures
46 records of P10412 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3TZD | Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3) | x-ray diffraction | T | — | — |
| 3TZD | Crystal structure of the complex of human chromobox homolog 3 (CBX3) | x-ray diffraction | T | — | — |
| 6H8P | JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer) | x-ray diffraction | C, D | NI, OGA | 3 (best 0.78) |
| 6H8P | JMJD2A/ KDM4A complexed with NI(II), nog and histone H1.4(18-32)K26ME3 peptide (15-mer) | x-ray diffraction | C, D | OGA | — |
| 7K5Y | Cryo-EM structure of a chromatosome containing human linker histone H1.4 | electron microscopy | U | — | 1 (best 0.57) |
| 7K5Y | Cryo-EM structure of a chromatosome containing human linker histone H1.4 | electron microscopy | U | — | — |
| 7PET | The 4x177 nucleosome array containing H1 | electron microscopy | u, s | — | — |
| 7PET | The 4X177 nucleosome array containing H1 | electron microscopy | u, s | — | — |
| 7PEU | Trinucleosome of the 4x177 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PEU | Trinucleosome of the 4X177 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PEX | Nucleosome 2 of the 4x177 nucleosome array containing H1 | electron microscopy | u | — | 1 (best 0.66) |
| 7PEX | Nucleosome 2 of the 4X177 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PEZ | Nucleosome 4 of the 4x177 nucleosome array containing H1 | electron microscopy | s | — | 1 (best 0.60) |
| 7PEZ | Nucleosome 4 of the 4X177 nucleosome array containing H1 | electron microscopy | s | — | — |
| 7PF0 | Trinucleosome of the 4x177 nucleosome array containing H1 | electron microscopy | u, U | — | — |
| 7PF0 | Trinucleosome of the 4X177 nucleosome array containing H1 | electron microscopy | u, U | — | — |
| 7PF2 | Nucleosome stack of the 4x187 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PF2 | Nucleosome stack of the 4X187 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PF3 | Nucleosome 4 of the 4x187 nucleosome array containing H1 | electron microscopy | s | — | — |
| 7PF3 | Nucleosome 4 of the 4X187 nucleosome array containing H1 | electron microscopy | s | — | — |
| 7PF5 | Nucleosome 2 of the 4x187 nucleosome array containing H1 | electron microscopy | u | — | 1 (best 0.54) |
| 7PF5 | Nucleosome 2 of the 4X187 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PF6 | Nucleosome 1 of the 4x187 nucleosome array containing H1 | electron microscopy | U | — | 1 (best 0.61) |
| 7PF6 | Nucleosome 1 of the 4X187 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFA | Trinucleosome of the 4x197 nucleosome array containing H1 | electron microscopy | U, u | — | — |
| 7PFA | Trinucleosome of the 4X197 nucleosome array containing H1 | electron microscopy | U, u | — | — |
| 7PFC | Nucleosome stack of the 4x197 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFC | Nucleosome stack of the 4X197 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFD | Nucleosome 1 of the 4x197 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFD | Nucleosome 1 of the 4X197 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFE | Nucleosome 2 of the 4x197 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PFE | Nucleosome 2 of the 4X197 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PFT | Trinucleosome of the 4x207 nucleosome array containing H1 | electron microscopy | U, u, S | — | — |
| 7PFT | Trinucleosome of the 4X207 nucleosome array containing H1 | electron microscopy | U, u, S | — | — |
| 7PFU | Nucleosome stack of the 4x207 nucleosome array containing H1 | electron microscopy | U, S | — | — |
| 7PFU | Nucleosome stack of the 4X207 nucleosome array containing H1 | electron microscopy | U, S | — | — |
| 7PFV | Nucleosome 1 of the 4x207 nucleosome array containing H1 | electron microscopy | U | — | 1 (best 0.58) |
| 7PFV | Nucleosome 1 of the 4X207 nucleosome array containing H1 | electron microscopy | U | — | — |
| 7PFW | Nucleosome 2 of the 4x207 nucleosome array containing H1 | electron microscopy | u | — | 1 (best 0.67) |
| 7PFW | Nucleosome 2 of the 4X207 nucleosome array containing H1 | electron microscopy | u | — | — |
| 7PFX | Nucleosome 3 of the 4x207 nucleosome array containing H1 | electron microscopy | S | — | 1 (best 0.55) |
| 7PFX | Nucleosome 3 of the 4X207 nucleosome array containing H1 | electron microscopy | S | — | — |
| 8H1T | Cryo-EM structure of BAP1-ASXL1 bound to chromatosome | electron microscopy | K | — | 3 (best 0.70) |
| 8VG2 | Cryo-EM structure of FoxA1 and GATA4 in complex with H14 chromatosome | electron microscopy | U | — | 1 (best 0.58) |
| 9DDE | ncPRC1RYBP bound to H2AK119Ub/H1.4 chromatosome | electron microscopy | O | — | 2 (best 0.61) |
| P10412 | AlphaFold monomer V2.0 prediction for histone H1.4 (P10412) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7K5Y chain U against the predicted model P10412: TM-score 0.92, RMSD 1.11 Å
- 7K5Y chain U against the predicted model P10412: TM-score 0.92, RMSD 1.11 Å
- 8VG2 chain U against the predicted model P10412: TM-score 0.92, RMSD 1.06 Å
- 7PFT chain S against the predicted model P10412: TM-score 0.92, RMSD 1.08 Å
- 7PFT chain S against the predicted model P10412: TM-score 0.92, RMSD 1.08 Å
- 7PFX chain S against the predicted model P10412: TM-score 0.92, RMSD 1.08 Å
- 7PFX chain S against the predicted model P10412: TM-score 0.92, RMSD 1.08 Å
- 7PFU chain S against the predicted model P10412: TM-score 0.91, RMSD 1.10 Å
- 7PFU chain S against the predicted model P10412: TM-score 0.91, RMSD 1.10 Å
- 7PFV chain U against the predicted model P10412: TM-score 0.91, RMSD 1.14 Å
Elsewhere
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