RAB27A fusion with SLP2A-RBDA1 effector covalent adduct with CB1 in C123

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 22% strand (DSSP).

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains A, B
• 05Y · ~{N}-[1-(2-pyridin-2-ylethyl)benzimidazol-2-yl]propanamide · ligand · 2 copies · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• GOL · Glycerol · additive · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1501 Ų buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

• 7OPR · Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123 · the same entry in another collection · chain A against A, TM-score 1.00
• P51159 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-27A (P51159) · a predicted model of the same protein · chain B against A, TM-score 0.85
• Q9HCH5 · AlphaFold monomer V2.0 prediction for synaptotagmin-like protein 2 (Q9HCH5) · a predicted model of the same protein · chain A against A, TM-score 0.28

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9HCH5
• Every structure of UniProt P51159
• Elsewhere: RCSB PDB 7OPR · PDBe 7OPR · UniProt Q9HCH5 · UniProt P51159