UniProt Q9HCH5
Synaptotagmin-like protein 2,Ras-related protein Rab-27A (Q9HCH5)
Synaptotagmin-like protein 2,Ras-related protein Rab-27A (UniProt Q9HCH5), EC 3.6.5.2: 13 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 40 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9HCH5
- Protein
- Synaptotagmin-like protein 2,Ras-related protein Rab-27A
- EC
- 3.6.5.2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 40 · 9 records with a druggable one
Structures
14 records of Q9HCH5 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BC1 | Crystal Structure of the complex Rab27a-Slp2a | x-ray diffraction | B, F | — | — |
| 3BC1 | Crystal structure of the complex RAB27A-SLP2A | x-ray diffraction | B, F | — | — |
| 7OPP | Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting | x-ray diffraction | A, C | GNP, MG | 6 (best 0.70) |
| 7OPP | Crystal structure of the RAB27A fusion with SLP2A-RBDA1 effector for SF4 pocket drug targeting | x-ray diffraction | A, C | GNP, MG | — |
| 7OPQ | Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188 | x-ray diffraction | A, B | 06D, GNP, MG | 4 (best 0.72) |
| 7OPQ | RAB27A fusion with SLP2A-RBDA1 effector covalent adduct with CA1 in C188 | x-ray diffraction | A, B | 06D, GNP, MG | — |
| 7OPR | Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123 | x-ray diffraction | A, B | GNP, MG, 05Y | 4 (best 0.73) |
| 7OPR | RAB27A fusion with SLP2A-RBDA1 effector covalent adduct with CB1 in C123 | x-ray diffraction | A, B | GNP, MG, 05Y | — |
| 8P3G | Fusion hSlp2-a_Rab27A bound to covalent hit fragment IMP-1704 | x-ray diffraction | A, B | GNP, WTU, MG | 5 (best 0.73) |
| 8P3H | Fusion hSlp2-a_Rab27A bound to covalent hit fragment IMP-1712 | x-ray diffraction | A, B | GNP, WTO, MG | 4 (best 0.74) |
| 8P3I | Fusion hSlp2-a_Rab27A bound to covalent hit fragment IMP-1721 | x-ray diffraction | A, B | GNP, WTK, MG | 5 (best 0.69) |
| 8P3J | Fusion hSlp2-a_Rab27A non-covalent complex with hit fragment IMP-1704 | x-ray diffraction | A, B | WT6, GNP, MG | 4 (best 0.71) |
| 8P3K | Fusion hSlp2-a_Rab27A non-covalent complex with compound IMP-2505 | x-ray diffraction | A, B | GNP, WTB, MG | 4 (best 0.60) |
| Q9HCH5 | AlphaFold monomer V2.0 prediction for synaptotagmin-like protein 2 (Q9HCH5) | predicted | A | — | 4 (best 0.71) |
Ligands
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 11 records
- MG · Magnesium ion · in 11 records
- 05Y · ~{N}-[1-(2-pyridin-2-ylethyl)benzimidazol-2-yl]propanamide · in 2 records
- 06D · 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one · in 2 records
- WT6 · ~{N}-(4-pyrrolidin-1-ylsulfonylphenyl)prop-2-enamide · in 1 record
- WTB · (2~{S})-~{N}-(3-methoxyphenyl)-1-[4-(prop-2-enoylamino)phenyl]sulfonyl-pyrrolidine-2-carboxamide · in 1 record
- WTK · ~{N}-(3-methoxy-4-pyrrolidin-1-ylsulfonyl-phenyl)propanamide · in 1 record
- WTO · methyl (2~{S})-1-[4-(propanoylamino)phenyl]sulfonylpyrrolidine-2-carboxylate · in 1 record
- WTU · ~{N}-(4-pyrrolidin-1-ylsulfonylphenyl)propanamide · in 1 record
Experiment against prediction
- 3BC1 chain F against the predicted model Q9HCH5: TM-score 0.89, RMSD 1.20 Å
- 3BC1 chain F against the predicted model Q9HCH5: TM-score 0.89, RMSD 1.20 Å
- 7OPQ chain B against the predicted model P51159: TM-score 0.86, RMSD 1.47 Å
- 7OPQ chain B against the predicted model P51159: TM-score 0.86, RMSD 1.47 Å
- 7OPQ chain A against the predicted model P51159: TM-score 0.86, RMSD 1.49 Å
- 7OPQ chain A against the predicted model P51159: TM-score 0.86, RMSD 1.49 Å
- 8P3G chain B against the predicted model P51159: TM-score 0.86, RMSD 1.60 Å
- 8P3H chain A against the predicted model P51159: TM-score 0.86, RMSD 1.31 Å
- 8P3G chain A against the predicted model P51159: TM-score 0.86, RMSD 1.40 Å
- 8P3H chain B against the predicted model P51159: TM-score 0.86, RMSD 1.31 Å
Elsewhere
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