MolNFT v1 · #184424 · protein

Crystal structure of the RAB27A fusion with SLP2A-RBDA1 effector for SF4 pocket drug targeting

7OPP: “Crystal structure of the RAB27A fusion with SLP2A-RBDA1 effector for SF4 pocket drug targeting”. X-ray diffraction, 2 ligands (GNP, MG). MolNFT v1 #184424 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OPP
Type: protein
Length: 419 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9HCH5, P51159
Ligands: GNP, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	210	—	Q9HCH5, P51159
C	—	protein	209	—	Q9HCH5, P51159

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains A, C
MG · Magnesium ion · metal · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7OPP · Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug… · the same entry in another collection · chain A against A, TM-score 1.00
P51159 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-27A (P51159) · a predicted model of the same protein · chain C against A, TM-score 0.85
Q9HCH5 · AlphaFold monomer V2.0 prediction for synaptotagmin-like protein 2 (Q9HCH5) · a predicted model of the same protein · chain C against A, TM-score 0.27

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HCH5
Every structure of UniProt P51159
Elsewhere: RCSB PDB 7OPP · PDBe 7OPP · UniProt Q9HCH5 · UniProt P51159

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