UniProt P51159
Synaptotagmin-like protein 2,Ras-related protein Rab-27A (P51159)
Synaptotagmin-like protein 2,Ras-related protein Rab-27A (UniProt P51159), EC 3.6.5.2: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 19 pockets. Binding sites, druggability and experiment against…
- UniProt
- P51159
- Protein
- Synaptotagmin-like protein 2,Ras-related protein Rab-27A
- EC
- 3.6.5.2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 19 · 5 records with a druggable one
Structures
9 records of P51159 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HUF | Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular… | x-ray diffraction | A, O, N, B, E, C, K, M, D, P, F, J, G, I, H, L | MG, GNP | — |
| 7OPP | Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting | x-ray diffraction | A, C | GNP, MG | 6 (best 0.70) |
| 7OPP | Crystal structure of the RAB27A fusion with SLP2A-RBDA1 effector for SF4 pocket drug targeting | x-ray diffraction | A, C | GNP, MG | — |
| 7OPQ | Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188 | x-ray diffraction | A, B | 06D, GNP, MG | 4 (best 0.72) |
| 7OPQ | RAB27A fusion with SLP2A-RBDA1 effector covalent adduct with CA1 in C188 | x-ray diffraction | A, B | 06D, GNP, MG | — |
| 7OPR | Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123 | x-ray diffraction | A, B | GNP, MG, 05Y | 4 (best 0.73) |
| 7OPR | RAB27A fusion with SLP2A-RBDA1 effector covalent adduct with CB1 in C123 | x-ray diffraction | A, B | GNP, MG, 05Y | — |
| 8P3J | Fusion hSlp2-a_Rab27A non-covalent complex with hit fragment IMP-1704 | x-ray diffraction | A, B | WT6, GNP, MG | 4 (best 0.71) |
| P51159 | AlphaFold monomer V2.0 prediction for RAS-related protein rab-27A (P51159) | predicted | A | — | 1 (best 0.55) |
Ligands
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 8 records
- MG · Magnesium ion · in 8 records
- 05Y · ~{N}-[1-(2-pyridin-2-ylethyl)benzimidazol-2-yl]propanamide · in 2 records
- 06D · 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one · in 2 records
- WT6 · ~{N}-(4-pyrrolidin-1-ylsulfonylphenyl)prop-2-enamide · in 1 record
Experiment against prediction
- 6HUF chain A against the predicted model P51159: TM-score 0.95, RMSD 1.05 Å
- 7OPQ chain B against the predicted model P51159: TM-score 0.86, RMSD 1.47 Å
- 7OPQ chain B against the predicted model P51159: TM-score 0.86, RMSD 1.47 Å
- 7OPQ chain A against the predicted model P51159: TM-score 0.86, RMSD 1.49 Å
- 7OPQ chain A against the predicted model P51159: TM-score 0.86, RMSD 1.49 Å
- 7OPP chain C against the predicted model P51159: TM-score 0.85, RMSD 1.26 Å
- 7OPP chain C against the predicted model P51159: TM-score 0.85, RMSD 1.26 Å
- 8P3J chain A against the predicted model P51159: TM-score 0.85, RMSD 1.75 Å
- 7OPP chain A against the predicted model P51159: TM-score 0.85, RMSD 1.28 Å
- 7OPP chain A against the predicted model P51159: TM-score 0.85, RMSD 1.28 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.