Research workbench
Oxyntomodulin-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein
Analyse Oxyntomodulin-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LLY
- Type
- protein
- Length
- 1,101 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P01274, P43220
- Pockets
- 12 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 196 | 44% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 339 | 6% helix, 46% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 58% helix, 0% strand | P59768 |
| N | NB35 | protein | 128 | 5% helix, 41% strand | — |
| P | Pro-glucagon | protein | 26 | 88% helix, 0% strand | P01274 |
| R | Glucagon-like peptide 1 receptor | protein | 355 | 67% helix, 4% strand | P43220 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.84 | 0.86 | 87 | empty |
| 2 | 837 | 0.76 | 0.80 | 63 | empty |
| 3 | 909 | 0.76 | 0.79 | 65 | empty |
| 4 | 488 | 0.70 | 0.80 | 66 | empty |
| 5 | 249 | 0.52 | 0.76 | 31 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2193 Ų buried · 14 hydrogen bonds · protein-protein
- P–R · 1452 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1445 Ų buried · 14 hydrogen bonds · protein-protein
- A–R · 999 Ų buried · 7 hydrogen bonds · protein-protein
- A–N · 893 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7LLY · Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.90
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.85
- P01274 · AlphaFold monomer V2.0 prediction for pro-glucagon (P01274) · a predicted model of the same protein · chain P against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P01274
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7LLY · PDBe 7LLY · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P01274 · UniProt P43220
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