Research workbench
Taspoglutide-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein
Analyse Taspoglutide-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KI1
- Type
- protein
- Length
- 1,285 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P43220
- Ligands
- NH2
- Pockets
- 12 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 349 | 49% helix, 12% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 47% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 56% helix, 0% strand | P59768 |
| N | NB35 | protein | 126 | 7% helix, 45% strand | — |
| R | Glucagon-like peptide 1 receptor | protein | 385 | 64% helix, 6% strand | P43220 |
| P | Taspoglutide | protein | 30 | 93% helix, 0% strand | — |
Ligands and binding sites
- NH2 · Amino group · ion · chains R, P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 703 | 0.82 | 0.86 | 56 | empty |
| 2 | 751 | 0.77 | 0.81 | 58 | empty |
| 3 | 1104 | 0.76 | 0.78 | 87 | empty |
| 4 | 478 | 0.74 | 0.83 | 47 | empty |
| 5 | 89 | 0.73 | 0.95 | 27 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2181 Ų buried · 17 hydrogen bonds · protein-protein
- R–P · 1869 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1486 Ų buried · 25 hydrogen bonds · protein-protein
- A–R · 1130 Ų buried · 6 hydrogen bonds · protein-protein
- A–N · 842 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 7KI1 · Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein · the same entry in another collection · chain P against P, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.94
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7KI1 · PDBe 7KI1 · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P43220
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.