Research workbench
Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to brimonidine
Analyse Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EJ8
- Type
- protein
- Length
- 1,100 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P09471, P62873, P59768, P08913
- Ligands
- J59
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 215 | — | P09471 |
| B | — | protein | 335 | — | P62873 |
| G | — | protein | 54 | — | P59768 |
| R | — | protein | 263 | — | P08913 |
| H | — | protein | 233 | — | — |
Ligands and binding sites
- J59 · Brimonidine · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EJ8 · Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine · the same entry in another collection · chain H against H, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P08913 · AlphaFold monomer V2.0 prediction for alpha-2A adrenergic receptor (P08913) · a predicted model of the same protein · chain R against A, TM-score 0.91
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.87
- P09471 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(O) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09471
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P08913
- Elsewhere: RCSB PDB 7EJ8 · PDBe 7EJ8 · UniProt P09471 · UniProt P62873 · UniProt P59768 · UniProt P08913
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