UniProt P08913
Alpha-2A adrenergic receptor (P08913)
Alpha-2A adrenergic receptor (UniProt P08913), EC 3.2.1.17: 21 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P08913
- Protein
- Alpha-2A adrenergic receptor
- EC
- 3.2.1.17
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 43 · 7 records with a druggable one
Structures
22 records of P08913 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HLL | NMR structure of T3-I2, a 32 residue peptide from the alpha-2A adrenergic receptor | solution nmr | A | — | — |
| 1HLL | NMR structure of T3-I2, a 32 residue peptide from the alpha-2A adrenergic receptor | solution nmr | A | — | — |
| 1HO9 | Best 20 NMR conformers of D130I mutant T3-I2, a 32 residue peptide from the alpha 2A adrenergic… | solution nmr | A | — | — |
| 1HO9 | Best 20 NMR conformers of D130I mutant T3-I2, a 32 residue peptide from the alpha 2A adrenergic… | solution nmr | A | — | — |
| 1HOD | NMR structure of D130I mutant T3-I2, a 32 residue peptide from the alpha 2A adrenergic receptor | solution nmr | A | — | — |
| 1HOD | NMR structure of D130I mutant T3-I2, a 32 residue peptide from the alpha 2A adrenergic receptor | solution nmr | A | — | — |
| 1HOF | NMR structure of T3-I2, a 32 residue peptide from the alpha-2A adrenergic receptor | solution nmr | A | — | — |
| 1HOF | NMR structure of T3-I2, a 32 residue peptide from the alpha-2A adrenergic receptor | solution nmr | A | — | — |
| 6K42 | cryo-EM structure of alpha2BAR-Gi1 complex | electron microscopy | R | CZX | 7 (best 0.80) |
| 6K42 | Cryo-EM structure of ALPHA2BAR-GI1 complex | electron microscopy | R | CZX | — |
| 7EJ0 | Structure of the alpha2A-adrenergic receptor GoA signaling complex | electron microscopy | R | E5E | 6 (best 0.75) |
| 7EJ0 | Structure of the ALPHA2A-adrenergic receptor goa signaling complex | electron microscopy | R | E5E | — |
| 7EJ8 | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine | electron microscopy | R | J59 | — |
| 7EJ8 | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to brimonidine | electron microscopy | R | J59 | — |
| 7EJA | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to dexmedetomidine | electron microscopy | R | CZX | — |
| 7EJK | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline | electron microscopy | R | J5C | 5 (best 0.82) |
| 7EJK | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to oxymetazoline | electron microscopy | R | J5C | — |
| 7W6P | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein… | electron microscopy | R | W96 | 6 (best 0.83) |
| 7W7E | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | electron microscopy | R | W58 | 7 (best 0.79) |
| 9CBL | Cryo-EM structure of epinephrine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric… | electron microscopy | R | ALE | 6 (best 0.74) |
| 9CBM | Cryo-EM structure of dexmedetomidine-bound alpha-2A-adrenergic receptor in complex with… | electron microscopy | R | CZX | 6 (best 0.76) |
| P08913 | AlphaFold monomer V2.0 prediction for alpha-2A adrenergic receptor (P08913) | predicted | A | — | — |
Ligands
- CZX · 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole · in 4 records
- E5E · Noradrenaline · in 2 records
- J59 · Brimonidine · in 2 records
- J5C · Oxymetazoline · in 2 records
- ALE · L-epinephrine · in 1 record
- W58 · 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine · in 1 record
- W96 · N-pyridin-4-ylisoquinolin-4-amine · in 1 record
Experiment against prediction
- 9CBM chain R against the predicted model P08913: TM-score 0.93, RMSD 1.96 Å
- 7W7E chain R against the predicted model P08913: TM-score 0.92, RMSD 2.15 Å
- 9CBL chain R against the predicted model P08913: TM-score 0.92, RMSD 2.09 Å
- 7W6P chain R against the predicted model P08913: TM-score 0.92, RMSD 2.21 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
- 7EJ8 chain R against the predicted model P08913: TM-score 0.91, RMSD 2.03 Å
- 7EJ8 chain R against the predicted model P08913: TM-score 0.91, RMSD 2.03 Å
- 7EJK chain R against the predicted model P08913: TM-score 0.91, RMSD 2.09 Å
- 7EJK chain R against the predicted model P08913: TM-score 0.91, RMSD 2.09 Å
Elsewhere
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