Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ and anthroylouabain (P4(3)2(1)2 symmetry)

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains A, B
• CLR · Cholesterol · ligand · 3 copies · chains A, B, G
• H0C · [(2~{R},3~{R},4~{R},5~{S},6~{S})-2-[[(1~{R},3~{S}, 5~{S},8~{R},9~{S},10~{R},11~{R},13~{R},14~{S},17~{R})-10-(hydroxymethyl)-13-methyl-1,5,11,14-tetrakis(oxidanyl)-17-(5-oxidanylidene-2~{H}-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl]oxy]-6-methyl-3,5-bis(oxidanyl)oxan-4-yl] anthracene-9-carboxylate · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains B
• MG · Magnesium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7D92 · Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and… · the same entry in another collection · chain A against A, TM-score 1.00
• P05024 · AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit… · a predicted model of the same protein · chain A against A, TM-score 0.97
• P05027 · AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit beta-1… · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P05024
• Every structure of UniProt P05027
• Every structure of UniProt Q58K79
• Elsewhere: RCSB PDB 7D92 · PDBe 7D92 · UniProt P05024 · UniProt P05027 · UniProt Q58K79