Research workbench
Cenp-a nucleosome bound by two copies of cenp-C(CD) and one copy cenp- N(NT)
Analyse Cenp-a nucleosome bound by two copies of cenp-C(CD) and one copy cenp- N(NT) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MUO
- Type
- protein + DNA
- Length
- 1,300 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3-like centromeric protein a; Histone H4; Histone H2A type 1-C; Histone H2B type…
- UniProt
- P49450, P62805, Q93077, Q5QNW6, Q03188, Q96H22
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 11 distinct chains · 46% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Histone H3-like centromeric protein a | protein | 99 | 56% helix, 2% strand | P49450 |
| B | Histone H4 | protein | 94 | 48% helix, 4% strand | P62805 |
| C | Histone H2A type 1-C | protein | 103 | 50% helix, 5% strand | Q93077 |
| D, H | Histone H2B type 2-F | protein | 92 | 64% helix, 3% strand | Q5QNW6 |
| F | Histone H4 | protein | 80 | 55% helix, 5% strand | P62805 |
| G | Histone H2A type 1-C | protein | 105 | 50% helix, 6% strand | Q93077 |
| I | DNA/RNA (147-mer) | dna | 147 | — | — |
| J | DNA/RNA (147-mer) | dna | 147 | — | — |
| K | Centromere protein C | protein | 19 | 0% helix, 0% strand | Q03188 |
| L | Centromere protein C | protein | 18 | 0% helix, 0% strand | Q03188 |
| M | Centromere protein N | protein | 205 | 33% helix, 17% strand | Q96H22 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1125 | 0.86 | 0.87 | 118 | empty |
| 2 | 808 | 0.85 | 0.88 | 85 | empty |
| 3 | 647 | 0.81 | 0.86 | 67 | empty |
| 4 | 582 | 0.78 | 0.85 | 61 | empty |
| 5 | 801 | 0.77 | 0.81 | 77 | empty |
Interfaces
52 interfaces between chains.
- I–J · 6301 Ų buried · 566 hydrogen bonds · nucleic-nucleic
- A–B · 2720 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 2675 Ų buried · 6 hydrogen bonds · protein-protein
- G–H · 2641 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2630 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6MUO · CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT) · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49450
- Every structure of UniProt P62805
- Every structure of UniProt Q93077
- Every structure of UniProt Q5QNW6
- Every structure of UniProt Q03188
- Every structure of UniProt Q96H22
- Elsewhere: RCSB PDB 6MUO · PDBe 6MUO · UniProt P49450 · UniProt P62805 · UniProt Q93077 · UniProt Q5QNW6 · UniProt Q03188 · UniProt Q96H22
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