UniProt P49450
Histone H3-like centromeric protein A (P49450)
Histone H3-like centromeric protein A (UniProt P49450): 51 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 131 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49450
- Protein
- Histone H3-like centromeric protein A
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 131 · 12 records with a druggable one
Structures
52 records of P49450 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AN2 | The structure of the centromeric nucleosome containing CENP-A | x-ray diffraction | A, E | — | — |
| 3AN2 | The structure of the centromeric nucleosome containing cenp-a | x-ray diffraction | A, E | — | — |
| 3NQJ | Crystal structure of (CENP-A/H4)2 heterotetramer | x-ray diffraction | A | — | — |
| 3NQJ | Crystal structure of (cenp-A/H4)2 heterotetramer | x-ray diffraction | A | — | — |
| 3NQU | Crystal structure of partially trypsinized (CENP-A/H4)2 heterotetramer | x-ray diffraction | A | — | — |
| 3NQU | Crystal structure of partially trypsinized (cenp-A/H4)2 heterotetramer | x-ray diffraction | A | — | — |
| 3R45 | Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP | x-ray diffraction | A | — | — |
| 3R45 | Structure of a cenp-a-histone H4 heterodimer in complex with chaperone hjurp | x-ray diffraction | A | — | — |
| 3WTP | Crystal Structure of the heterotypic nucleosome containing human CENP-A and H3.3 | x-ray diffraction | A | — | — |
| 3WTP | Crystal structure of the heterotypic nucleosome containing human cenp- a and H3.3 | x-ray diffraction | A | — | — |
| 5CVD | Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human CENP-A peptide | x-ray diffraction | D, E | SAH | 4 (best 0.80) |
| 5CVD | Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human cenp-a peptide | x-ray diffraction | D, E | — | — |
| 5Z23 | Crystal structure of the nucleosome containing a chimeric histone H3/CENP-A CATD | x-ray diffraction | A, E | — | 12 (best 0.77) |
| 5Z23 | Crystal structure of the nucleosome containing a chimeric histone H3/CENP-a catd | x-ray diffraction | A, E | — | — |
| 5ZBX | The crystal structure of the nucleosome containing histone H3.1 CATD(V76Q, K77D) | x-ray diffraction | A, E | MN | — |
| 6BUZ | Cryo-EM structure of cenp-a nucleosome in complex with kinetochore protein cenp-N | electron microscopy | A, E | — | — |
| 6C0W | Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing… | electron microscopy | A, E | — | 13 (best 0.84) |
| 6C0W | Cryo-EM structure of human kinetochore protein cenp-N with the centromeric nucleosome containing… | electron microscopy | A, E | — | — |
| 6E0C | Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment | electron microscopy | A, E | — | 10 (best 0.82) |
| 6E0C | Cryo-EM structure of the cenp-a nucleosome (W601) in complex with a single chain antibody fragment | electron microscopy | A, E | — | — |
| 6E0P | Cryo-EM structure of the centromeric nucleosome (Native alpha satellite DNA) in complex with a… | electron microscopy | A, E | — | 10 (best 0.88) |
| 6E0P | Cryo-EM structure of the centromeric nucleosome (native alpha satellite DNA) in complex with a… | electron microscopy | A, E | — | — |
| 6L49 | H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA | electron microscopy | A, E | — | — |
| 6L49 | H3-ca-H3 tri-nucleosome with the 22 base-pair linker DNA | electron microscopy | A, E | — | — |
| 6MUO | CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT) | electron microscopy | A, E | — | 13 (best 0.86) |
| 6MUO | Cenp-a nucleosome bound by two copies of cenp-C(CD) and one copy cenp- N(NT) | electron microscopy | A, E | — | — |
| 6MUP | CENP-A nucleosome bound by two copies of CENP-C(CD) and two copies CENP-N(NT) | electron microscopy | A, E | — | 13 (best 0.85) |
| 6MUP | Cenp-a nucleosome bound by two copies of cenp-C(CD) and two copies cenp-N(NT) | electron microscopy | A, E | — | — |
| 6O1D | Cryo-EM structure of the centromeric nucleosome with native alpha satellite DNA | electron microscopy | A, E | — | 14 (best 0.85) |
| 6O1D | Cryo-EM structure of the centromeric nucleosome with native alpha satellite DNA | electron microscopy | A, E | — | — |
| 6SE0 | Class 1 : CENP-A nucleosome | electron microscopy | A, E | — | 14 (best 0.80) |
| 6SE0 | Class 1 : cenp-a nucleosome | electron microscopy | A, E | — | — |
| 6SE6 | Class2 : CENP-A nucleosome in complex with CENP-C central region | electron microscopy | A, E | — | — |
| 6SE6 | CLASS2 : cenp-a nucleosome in complex with cenp-C central region | electron microscopy | A, E | — | — |
| 6SEE | CLASS2A : cenp-a nucleosome in complex with cenp-C central region | electron microscopy | A, E | — | — |
| 6SEF | CLASS2C : cenp-a nucleosome in complex with cenp-C central region | electron microscopy | A, E | — | — |
| 6SEG | Class1: CENP-A nucleosome in complex with CENP-C central region | electron microscopy | A, E | — | 13 (best 0.85) |
| 6SEG | CLASS1: cenp-a nucleosome in complex with cenp-C central region | electron microscopy | A, E | — | — |
| 6TEM | Cenp-a nucleosome core particle with 145 base pairs of the widom 601 sequence by cryo-EM | electron microscopy | A, E | — | — |
| 7D20 | Cryo-EM structure of SET8-CENP-A-nucleosome complex | electron microscopy | A, E | — | — |
| 7D20 | Cryo-EM structure of SET8-cenp-a-nucleosome complex | electron microscopy | A, E | — | — |
| 7PII | Structure of the human ccan cenp-a alpha-satellite complex | electron microscopy | A, E | — | — |
| 7R5R | Structure of the human ccan cenp-a alpha-satellite complex | electron microscopy | A, E | — | — |
| 7U46 | Cryo-EM structure of cenp-a nucleosome (palindromic alpha satellite DNA) in complex with cenp-N | electron microscopy | A, E | — | — |
| 7U47 | Cryoem structure of cenp-N promoted nucleosome stacks with cenp-a and palindromic alpha satellite… | electron microscopy | A, E, L, P | — | — |
| 7U4D | CryoEM structure of CENP-N promoted nucleosome stacks with CENP-A and 601 DNA sequence | electron microscopy | A, E, L, P | — | 11 (best 0.83) |
| 7U4D | Cryoem structure of cenp-N promoted nucleosome stacks with cenp-a and 601 DNA sequence | electron microscopy | A, E, L, P | — | — |
| 7YWX | Structure of the human CCAN CENP-A alpha-satellite complex | electron microscopy | A, E | — | — |
| 7YWX | Structure of the human ccan cenp-a alpha-satellite complex | electron microscopy | A, E | — | — |
| 7YYH | Structure of the human CCANdeltaT CENP-A alpha-satellite complex | electron microscopy | A, E | — | 4 (best 0.83) |
| 7YYH | Structure of the human ccandeltat cenp-a alpha-satellite complex | electron microscopy | A, E | — | — |
| P49450 | AlphaFold monomer V2.0 prediction for histone H3-like centromeric protein a (P49450) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7D20 chain A against the predicted model P49450: TM-score 0.98, RMSD 0.45 Å
- 7D20 chain A against the predicted model P49450: TM-score 0.98, RMSD 0.45 Å
- 3WTP chain A against the predicted model P49450: TM-score 0.98, RMSD 0.50 Å
- 3WTP chain A against the predicted model P49450: TM-score 0.98, RMSD 0.50 Å
- 7D20 chain E against the predicted model P49450: TM-score 0.98, RMSD 0.57 Å
- 7D20 chain E against the predicted model P49450: TM-score 0.98, RMSD 0.57 Å
- 7U46 chain A against the predicted model P49450: TM-score 0.98, RMSD 0.54 Å
- 7U47 chain A against the predicted model P49450: TM-score 0.98, RMSD 0.54 Å
- 7U47 chain L against the predicted model P49450: TM-score 0.98, RMSD 0.54 Å
- 6SEG chain A against the predicted model P49450: TM-score 0.98, RMSD 0.63 Å
Elsewhere
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