UniProt Q96H22
Centromere protein N (Q96H22)
Centromere protein N (UniProt Q96H22): 28 experimental structures and 1 predicted model on GenesisL1, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96H22
- Protein
- Centromere protein N
- Experimental structures
- 28
- Predicted models
- 1
- Pockets
- 58 · 13 records with a druggable one
Structures
29 records of Q96H22 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BUZ | Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N | electron microscopy | N | — | 3 (best 0.70) |
| 6BUZ | Cryo-EM structure of cenp-a nucleosome in complex with kinetochore protein cenp-N | electron microscopy | N | — | — |
| 6C0W | Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing… | electron microscopy | K | — | 3 (best 0.84) |
| 6C0W | Cryo-EM structure of human kinetochore protein cenp-N with the centromeric nucleosome containing… | electron microscopy | K | — | — |
| 6EQT | Crystal structure of the human kinetochore protein cenp-N | x-ray diffraction | A, B | — | 8 (best 0.64) |
| 6EQT | Crystal structure of the human kinetochore protein cenp-N | x-ray diffraction | A, B | — | — |
| 6MUO | CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT) | electron microscopy | M | — | 4 (best 0.85) |
| 6MUO | Cenp-a nucleosome bound by two copies of cenp-C(CD) and one copy cenp- N(NT) | electron microscopy | M | — | — |
| 6MUP | CENP-A nucleosome bound by two copies of CENP-C(CD) and two copies CENP-N(NT) | electron microscopy | M, N | — | 6 (best 0.83) |
| 6MUP | Cenp-a nucleosome bound by two copies of cenp-C(CD) and two copies cenp-N(NT) | electron microscopy | M, N | — | — |
| 7PKN | Structure of the human CCAN deltaCT complex | electron microscopy | N | — | 3 (best 0.65) |
| 7PKN | Structure of the human ccan deltact complex | electron microscopy | N | — | — |
| 7QOO | Structure of the human inner kinetochore CCAN complex | electron microscopy | N | — | 2 (best 0.78) |
| 7QOO | Structure of the human inner kinetochore ccan complex | electron microscopy | N | — | — |
| 7R5S | Structure of the human CCAN bound to alpha satellite DNA | electron microscopy | N | — | 3 (best 0.66) |
| 7R5S | Structure of the human ccan bound to alpha satellite DNA | electron microscopy | N | — | — |
| 7R5V | Structure of the human CCAN CENP-A alpha-satellite complex | electron microscopy | N | — | 4 (best 0.77) |
| 7R5V | Structure of the human ccan cenp-a alpha-satellite complex | electron microscopy | N | — | — |
| 7U46 | Cryo-EM structure of cenp-a nucleosome (palindromic alpha satellite DNA) in complex with cenp-N | electron microscopy | K | — | — |
| 7U47 | Cryoem structure of cenp-N promoted nucleosome stacks with cenp-a and palindromic alpha satellite… | electron microscopy | K, V | — | — |
| 7U4D | CryoEM structure of CENP-N promoted nucleosome stacks with CENP-A and 601 DNA sequence | electron microscopy | K, V | — | 11 (best 0.83) |
| 7U4D | Cryoem structure of cenp-N promoted nucleosome stacks with cenp-a and 601 DNA sequence | electron microscopy | K, V | — | — |
| 7XHN | Structure of human inner kinetochore CCAN-DNA complex | electron microscopy | N | — | 4 (best 0.80) |
| 7XHO | Structure of human inner kinetochore CCAN complex | electron microscopy | N | — | 5 (best 0.53) |
| 7YWX | Structure of the human CCAN CENP-A alpha-satellite complex | electron microscopy | N | — | — |
| 7YWX | Structure of the human ccan cenp-a alpha-satellite complex | electron microscopy | N | — | — |
| 7YYH | Structure of the human CCANdeltaT CENP-A alpha-satellite complex | electron microscopy | N | — | 2 (best 0.80) |
| 7YYH | Structure of the human ccandeltat cenp-a alpha-satellite complex | electron microscopy | N | — | — |
| Q96H22 | AlphaFold monomer V2.0 prediction for centromere protein N (Q96H22) | predicted | A | — | — |
Experiment against prediction
- 6EQT chain B against the predicted model Q96H22: TM-score 0.96, RMSD 1.60 Å
- 6EQT chain B against the predicted model Q96H22: TM-score 0.96, RMSD 1.60 Å
- 7U47 chain V against the predicted model Q96H22: TM-score 0.96, RMSD 1.58 Å
- 7U46 chain K against the predicted model Q96H22: TM-score 0.96, RMSD 1.58 Å
- 7U47 chain K against the predicted model Q96H22: TM-score 0.96, RMSD 1.58 Å
- 6EQT chain A against the predicted model Q96H22: TM-score 0.96, RMSD 1.43 Å
- 6EQT chain A against the predicted model Q96H22: TM-score 0.96, RMSD 1.43 Å
- 7YYH chain N against the predicted model Q96H22: TM-score 0.95, RMSD 1.60 Å
- 7YYH chain N against the predicted model Q96H22: TM-score 0.95, RMSD 1.60 Å
- 7R5V chain N against the predicted model Q96H22: TM-score 0.95, RMSD 1.61 Å
Elsewhere
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