MolNFT v1 · #186203 · protein + DNA
Structure of the human ccan cenp-a alpha-satellite complex
7R5V · Centromere protein H: “Structure of the human ccan cenp-a alpha-satellite complex”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #186203 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7R5V
- Type
- protein + DNA
- Length
- 2,201 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein H; Centromere protein I; DNA (171-mer); Centromere protein K…
- UniProt
- Q9H3R5, Q92674, Q9BS16, Q8N0S6, Q9NSP4, Q96H22, Q9BU64, Q6IPU0, Q7L2Z9, Q71F23, Q13352
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 13 distinct chains · 57% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Centromere protein H | protein | 124 | 93% helix, 0% strand | Q9H3R5 |
| I | Centromere protein I | protein | 328 | 67% helix, 0% strand | Q92674 |
| J | DNA (171-mer) | dna | 32 | — | — |
| K | Centromere protein K | protein | 126 | 87% helix, 0% strand | Q9BS16 |
| L | Centromere protein L | protein | 297 | 39% helix, 25% strand | Q8N0S6 |
| M | Centromere protein M | protein | 172 | 38% helix, 19% strand | Q9NSP4 |
| N | Centromere protein N | protein | 297 | 42% helix, 21% strand | Q96H22 |
| O | Centromere protein O | protein | 210 | 44% helix, 21% strand | Q9BU64 |
| P | Centromere protein P | protein | 219 | 42% helix, 32% strand | Q6IPU0 |
| Q | Centromere protein Q | protein | 189 | 72% helix, 1% strand | Q7L2Z9 |
| U | Centromere protein U | protein | 165 | 88% helix, 0% strand | Q71F23 |
| i | DNA (171-mer) | dna | 31 | — | — |
| R | Centromere protein R | protein | 11 | 82% helix, 0% strand | Q13352 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 714 | 0.85 | 0.88 | 79 | empty |
| 2 | 599 | 0.83 | 0.88 | 62 | empty |
| 3 | 406 | 0.82 | 0.90 | 73 | empty |
| 4 | 464 | 0.81 | 0.88 | 58 | empty |
| 5 | 153 | 0.80 | 0.95 | 34 | empty |
Interfaces
27 interfaces between chains.
- Q–U · 3155 Ų buried · 8 hydrogen bonds · protein-protein
- H–K · 2987 Ų buried · 16 hydrogen bonds · protein-protein
- H–I · 1692 Ų buried · 15 hydrogen bonds · protein-protein
- O–P · 1670 Ų buried · 15 hydrogen bonds · protein-protein
- P–U · 1459 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7R5V · Structure of the human CCAN CENP-A alpha-satellite complex · the same entry in another collection · chain R against R, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3R5
- Every structure of UniProt Q92674
- Every structure of UniProt Q9BS16
- Every structure of UniProt Q8N0S6
- Every structure of UniProt Q9NSP4
- Every structure of UniProt Q96H22
- Every structure of UniProt Q9BU64
- Every structure of UniProt Q6IPU0
- Every structure of UniProt Q7L2Z9
- Every structure of UniProt Q71F23
- Every structure of UniProt Q13352
- Elsewhere: RCSB PDB 7R5V · PDBe 7R5V · UniProt Q9H3R5 · UniProt Q92674 · UniProt Q9BS16 · UniProt Q8N0S6 · UniProt Q9NSP4 · UniProt Q96H22 · UniProt Q9BU64 · UniProt Q6IPU0 · UniProt Q7L2Z9 · UniProt Q71F23 · UniProt Q13352
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