Structural determinants of activation and biased agonism at the 5-HT2B receptor

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).

Ligands and binding sites

• H8D · (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide · ligand · chains A
• CLR · Cholesterol · ligand · chains A
• OLA · Oleic acid · ligand · chains A
• PO4 · Phosphate ion · ion · 2 copies · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 6DRY · Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor · the same entry in another collection · chain A against A, TM-score 1.00
• P41595 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2B (P41595) · a predicted model of the same protein · chain A against A, TM-score 0.78
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.28

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P41595
• Every structure of UniProt P0ABE7
• Elsewhere: RCSB PDB 6DRY · PDBe 6DRY · UniProt P41595 · UniProt P0ABE7