UniProt P41595
5HT2B receptor, BRIL chimera (P41595)
5HT2B receptor, BRIL chimera (UniProt P41595): 17 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41595
- Protein
- 5HT2B receptor, BRIL chimera
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 25 · 7 records with a druggable one
Structures
18 records of P41595 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IB4 | Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine | x-ray diffraction | A | — | — |
| 4IB4 | Crystal structure of the chimeric protein of 5-HT2B-bril in complex with ergotamine | x-ray diffraction | A | — | — |
| 4NC3 | Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic… | x-ray diffraction | A | — | — |
| 4NC3 | Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic… | x-ray diffraction | A | — | — |
| 5TUD | Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an… | x-ray diffraction | A, D | ERM | 7 (best 0.82) |
| 5TUD | Structural insights into the extracellular recognition of the human serotonin 2B receptor by an… | x-ray diffraction | A, D | ERM | — |
| 5TVN | Crystal structure of the LSD-bound 5-HT2B receptor | x-ray diffraction | A | 7LD, CLR, PO4 | 2 (best 0.78) |
| 5TVN | Crystal structure of the lsd-bound 5-HT2B receptor | x-ray diffraction | A | 7LD, CLR, PO4 | — |
| 6DRX | Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | x-ray diffraction | A | H8G, CLR | 4 (best 0.78) |
| 6DRX | Structural determinants of activation and biased agonism at the 5-HT2B receptor | x-ray diffraction | A | H8G, CLR | — |
| 6DRY | Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | x-ray diffraction | A | H8D, CLR, OLA, PO4 | 3 (best 0.80) |
| 6DRY | Structural determinants of activation and biased agonism at the 5-HT2B receptor | x-ray diffraction | A | H8D, CLR, OLA, PO4 | — |
| 6DRZ | Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | x-ray diffraction | A | CLR, OLA, PO4, H8J | 2 (best 0.77) |
| 6DRZ | Structural determinants of activation and biased agonism at the 5-HT2B receptor | x-ray diffraction | A | CLR, OLA, PO4, H8J | — |
| 6DS0 | Structural determinants of activation and biased agonism at the 5-HT2B receptor | x-ray diffraction | A | CLR, H8M | — |
| 7SRQ | 5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM) | electron microscopy | R | NAG, 7LD | 3 (best 0.80) |
| 7SRR | 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by… | electron microscopy | R | 7LD | 4 (best 0.78) |
| P41595 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2B (P41595) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 9 records
- PO4 · Phosphate ion · in 6 records
- 7LD · (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide · in 4 records
- OLA · Oleic acid · in 4 records
- ERM · Ergotamine · in 2 records
- H8D · (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide · in 2 records
- H8G · N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea · in 2 records
- H8J · (8alpha)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9, 10-didehydroergoline-8-carboxamide · in 2 records
- H8M · (1S)-1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 7SRQ chain R against the predicted model P41595: TM-score 0.95, RMSD 1.50 Å
- 7SRR chain R against the predicted model P41595: TM-score 0.94, RMSD 1.81 Å
- 6DRX chain A against the predicted model P41595: TM-score 0.82, RMSD 2.61 Å
- 6DRX chain A against the predicted model P41595: TM-score 0.82, RMSD 2.61 Å
- 6DS0 chain A against the predicted model P41595: TM-score 0.82, RMSD 2.55 Å
- 4NC3 chain A against the predicted model P41595: TM-score 0.82, RMSD 2.66 Å
- 4NC3 chain A against the predicted model P41595: TM-score 0.82, RMSD 2.66 Å
- 4IB4 chain A against the predicted model P41595: TM-score 0.81, RMSD 2.68 Å
- 4IB4 chain A against the predicted model P41595: TM-score 0.81, RMSD 2.68 Å
- 5TUD chain D against the predicted model P0ABE7: TM-score 0.30, RMSD 1.68 Å
Elsewhere
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