Ligand · H8D
H8D · (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide
H8D, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide (C20 H25 N3 O2, 339.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within…
- Component
- H8D
- Formula
- C20 H25 N3 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
H8D in 4 structures; the first of them:
- 6DRY · Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor · H8D A2001 · binds ASP135, VAL136, SER139, THR140, CYS207, VAL208, LEU209, PHE217 and 12 more
- 7UM7 · CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine · H8D A401 · binds TRP117, ILE118, ASP121, VAL122, CYS125, THR126, CYS192, VAL194 and 7 more
- 6DRY · Structural determinants of activation and biased agonism at the 5-HT2B receptor · H8D A2001 · binds ASP135, VAL136, SER139, THR140, VAL208, LEU209, PHE217, GLY221 and 8 more
- 7UM7 · Cryoem structure of go-coupled 5-HT5AR in complex with methylergometrine · H8D A401 · binds TRP117, ILE118, ASP121, VAL122, CYS125, THR126, SER204, TRP298 and 3 more
Residues it binds most
VAL 4, PHE 4, LEU 4, SER 4, TRP 3, ASP 4, CYS 3, THR 4, TYR 4, ALA 3 (residue and the binding sites it lines).
Found with
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